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Overfeeding during a critical postnatal period exacerbates hypothalamic-pituitary-adrenal axis responses to immune challenge: a role for adrenal melanocortin 2 receptors

Cai, Guohui, Ziko, Ilvana, Barwood, Joanne, Soch, Alita, Sominsky, Luba, Molero, Juan C. and Spencer, Sarah J. 2016, Overfeeding during a critical postnatal period exacerbates hypothalamic-pituitary-adrenal axis responses to immune challenge: a role for adrenal melanocortin 2 receptors, Scientific reports, vol. 6, pp. 1-10, doi: 10.1038/srep21097.

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Title Overfeeding during a critical postnatal period exacerbates hypothalamic-pituitary-adrenal axis responses to immune challenge: a role for adrenal melanocortin 2 receptors
Author(s) Cai, Guohui
Ziko, Ilvana
Barwood, Joanne
Soch, Alita
Sominsky, Luba
Molero, Juan C.
Spencer, Sarah J.
Journal name Scientific reports
Volume number 6
Article ID 21097
Start page 1
End page 10
Total pages 10
Publisher Nature
Place of publication London, Eng.
Publication date 2016-02-12
ISSN 2045-2322
Keyword(s) Adrenocorticotropic Hormone
Animals
Animals, Newborn
Bacterial Infections
Feeding Behavior
Female
Hypothalamo-Hypophyseal System
Lipopolysaccharides
Pituitary-Adrenal System
Rats
Receptor, Melanocortin, Type 2
Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
CORTICOSTERONE STRESS RESPONSES
PRIMARY CULTURE
MATERNAL-CARE
LONG-TERM
RAT
LIPOPOLYSACCHARIDE
OBESITY
LIFE
MECHANISMS
GLAND
Summary Early life diet can critically program hypothalamic-pituitary-adrenal (HPA) axis function. We have previously shown rats that are overfed as neonates have exacerbated pro-inflammatory responses to immune challenge with lipopolysaccharide (LPS), in part by altering HPA axis responses, but how this occurs is unknown. Here we examined neonatal overfeeding-induced changes in gene expression in each step of the HPA axis. We saw no differences in glucocorticoid or mineralocorticoid receptor expression in key regions responsible for glucocorticoid negative feedback to the brain and no differences in expression of key HPA axis regulatory genes in the paraventricular  nucleus of the hypothalamus or pituitary. On the other hand, expression of the adrenal melanocortin 2 receptor (MC2R) is elevated after LPS in control rats, but significantly less so in the neonatally overfed. The in vitro adrenal response to ACTH is also dampened in these rats, while the in vivo response to ACTH does not resolve as efficiently as it does in controls. These data suggest neonatal diet affects the
efficiency of the adrenally-mediated response to LPS, potentially influencing how neonatally overfed rats combat bacterial infection.
Language eng
DOI 10.1038/srep21097
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2016, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30112102

Document type: Journal Article
Collections: School of Exercise and Nutrition Sciences
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.