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Association between birthweight and later body mass index: an individual-based pooled analysis of 27 twin cohorts participating in the CODATwins project

Jelenkovic, Aline, Yokoyama, Yoshie, Sund, Reijo, Pietiläinen, Kirsi H., Hur, Yoon-Mi, Willemsen, Gonneke, Bartels, Meike, van Beijsterveldt, Toos CEM, Ooki, Syuichi, Saudino, Kimberly J., Stazi, Maria A., Fagnani, Carrado, D'Ippolito, Cristina, Nelson, Tracy L., Whitfield, Keith E., Knafo-Noam, Ariel, Mankuta, David, Abramson, Lior, Heikkilä, Kauko, Cutler, Tessa L., Hopper, John L., Wardle, Jane, Llewellyn, Clare H., Fisher, Abigail, Corley, Robin P., Huibregtse, Brooke M., Derom, Catherine A., Vlietinck, Robert F., Loos, Ruth J. F., Bjerregaard-Andersen, Morten, Beck-Nielsen, Henning, Sodemann, Morten, Tarnoki, Adam D., Tarnoki, David L., Burt, S. Alexandra, Klump, Kelly L., Ordoñana, Juan R., Sánchez-Romera, Juan F., Colodro-Conde, Lucia, Dubois, Lise, Boivin, Michel, Brendgen, Mara, Dionne, Ginette, Vitaro, Frank, Harris, Jennifer R., Brandt, Ingunn, Nilsen, Thomas Sevenius, Craig, Jeffrey M., Saffery, Richard, Rasmussen, Finn, Tynelius, Per, Bayasgalan, Gombojav, Narandalai, Danshiitsoodol, Haworth, Claire M. A., Plomin, Robert, Ji, Fuling, Ning, Feng, Pang, Zengchang, Rebato, Esther, Krueger, Robert F., McGue, Matt, Pahlen, Shandell, Boomsma, Dorret I., Sørensen, Thorkild I. A., Kaprio, Jaakko and Silventoinen, Karri 2017, Association between birthweight and later body mass index: an individual-based pooled analysis of 27 twin cohorts participating in the CODATwins project, International journal of epidemiology, vol. 46, no. 5, pp. 1488-1498, doi: 10.1093/ije/dyx031.

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Title Association between birthweight and later body mass index: an individual-based pooled analysis of 27 twin cohorts participating in the CODATwins project
Author(s) Jelenkovic, Aline
Yokoyama, Yoshie
Sund, Reijo
Pietiläinen, Kirsi H.
Hur, Yoon-Mi
Willemsen, Gonneke
Bartels, Meike
van Beijsterveldt, Toos CEM
Ooki, Syuichi
Saudino, Kimberly J.
Stazi, Maria A.
Fagnani, Carrado
D'Ippolito, Cristina
Nelson, Tracy L.
Whitfield, Keith E.
Knafo-Noam, Ariel
Mankuta, David
Abramson, Lior
Heikkilä, Kauko
Cutler, Tessa L.
Hopper, John L.
Wardle, Jane
Llewellyn, Clare H.
Fisher, Abigail
Corley, Robin P.
Huibregtse, Brooke M.
Derom, Catherine A.
Vlietinck, Robert F.
Loos, Ruth J. F.
Bjerregaard-Andersen, Morten
Beck-Nielsen, Henning
Sodemann, Morten
Tarnoki, Adam D.
Tarnoki, David L.
Burt, S. Alexandra
Klump, Kelly L.
Ordoñana, Juan R.
Sánchez-Romera, Juan F.
Colodro-Conde, Lucia
Dubois, Lise
Boivin, Michel
Brendgen, Mara
Dionne, Ginette
Vitaro, Frank
Harris, Jennifer R.
Brandt, Ingunn
Nilsen, Thomas Sevenius
Craig, Jeffrey M.
Saffery, Richard
Rasmussen, Finn
Tynelius, Per
Bayasgalan, Gombojav
Narandalai, Danshiitsoodol
Haworth, Claire M. A.
Plomin, Robert
Ji, Fuling
Ning, Feng
Pang, Zengchang
Rebato, Esther
Krueger, Robert F.
McGue, Matt
Pahlen, Shandell
Boomsma, Dorret I.
Sørensen, Thorkild I. A.
Kaprio, Jaakko
Silventoinen, Karri
Journal name International journal of epidemiology
Volume number 46
Issue number 5
Start page 1488
End page 1498
Total pages 11
Publisher Oxford University Press
Place of publication Oxford, Eng.
Publication date 2017-10
ISSN 0300-5771
1464-3685
Keyword(s) birthweight
body mass index
twins
Adolescent
Adult
Birth Weight
Child
Child, Preschool
Female
Humans
Infant
Internationality
Linear Models
Male
Middle Aged
Twins, Dizygotic
Twins, Monozygotic
Young Adult
Summary Background: There is evidence that birthweight is positively associated with body mass index (BMI) in later life, but it remains unclear whether this is explained by genetic factors or the intrauterine environment. We analysed the association between birthweight and BMI from infancy to adulthood within twin pairs, which provides insights into the role of genetic and environmental individual-specific factors.

Methods: This study is based on the data from 27 twin cohorts in 17 countries. The pooled data included 78 642 twin individuals (20 635 monozygotic and 18 686 same-sex dizygotic twin pairs) with information on birthweight and a total of 214 930 BMI measurements at ages ranging from 1 to 49 years. The association between birthweight and BMI was analysed at both the individual and within-pair levels using linear regression analyses.

Results: At the individual level, a 1-kg increase in birthweight was linearly associated with up to 0.9 kg/m2 higher BMI (P < 0.001). Within twin pairs, regression coefficients were generally greater (up to 1.2 kg/m2 per kg birthweight, P < 0.001) than those from the individual-level analyses. Intra-pair associations between birthweight and later BMI were similar in both zygosity groups and sexes and were lower in adulthood.

Conclusions: These findings indicate that environmental factors unique to each individual have an important role in the positive association between birthweight and later BMI, at least until young adulthood.
Language eng
DOI 10.1093/ije/dyx031
Field of Research 0104 Statistics
1117 Public Health And Health Services
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2017, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30112323

Document type: Journal Article
Collections: School of Medicine
Open Access Collection
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.