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The response of muscle protein synthesis following whole-body resistance exercise is greater following 40 g than 20 g of ingested whey protein

Macnaughton, Lindsay S., Wardle, Sophie L., Witard, Oliver C., McGlory, Chris, Hamilton, D. Lee, Jeromson, Stewart, Lawrence, Clare E., Wallis, Gareth A. and Tipton, Kevin D. 2016, The response of muscle protein synthesis following whole-body resistance exercise is greater following 40 g than 20 g of ingested whey protein, Physiological reports, vol. 4, no. 15, doi: 10.14814/phy2.12893.

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Title The response of muscle protein synthesis following whole-body resistance exercise is greater following 40 g than 20 g of ingested whey protein
Author(s) Macnaughton, Lindsay S.
Wardle, Sophie L.
Witard, Oliver C.
McGlory, Chris
Hamilton, D. Lee
Jeromson, Stewart
Lawrence, Clare E.
Wallis, Gareth A.
Tipton, Kevin D.
Journal name Physiological reports
Volume number 4
Issue number 15
Article ID e12893
Total pages 13
Publisher Wiley
Place of publication Bethesda, Md.
Publication date 2016-08
ISSN 2051-817X
Keyword(s) Fractional synthesis rate
intracellular signaling proteins
lean body mass
protein dose‐response
Adult
Amino Acids
Body Weights and Measures
Exercise
Humans
Male
Muscle Proteins
Muscle, Skeletal
Myofibrils
Phenylalanine
Urea
Whey Proteins
Young Adult
Summary The currently accepted amount of protein required to achieve maximal stimulation of myofibrillar protein synthesis (MPS) following resistance exercise is 20-25 g. However, the influence of lean body mass (LBM) on the response of MPS to protein ingestion is unclear. Our aim was to assess the influence of LBM, both total and the amount activated during exercise, on the maximal response of MPS to ingestion of 20 or 40 g of whey protein following a bout of whole-body resistance exercise. Resistance-trained males were assigned to a group with lower LBM (≤65 kg; LLBM n = 15) or higher LBM (≥70 kg; HLBM n = 15) and participated in two trials in random order. MPS was measured with the infusion of (13)C6-phenylalanine tracer and collection of muscle biopsies following ingestion of either 20 or 40 g protein during recovery from a single bout of whole-body resistance exercise. A similar response of MPS during exercise recovery was observed between LBM groups following protein ingestion (20 g - LLBM: 0.048 ± 0.018%·h(-1); HLBM: 0.051 ± 0.014%·h(-1); 40 g - LLBM: 0.059 ± 0.021%·h(-1); HLBM: 0.059 ± 0.012%·h(-1)). Overall (groups combined), MPS was stimulated to a greater extent following ingestion of 40 g (0.059 ± 0.020%·h(-1)) compared with 20 g (0.049 ± 0.020%·h(-1); P = 0.005) of protein. Our data indicate that ingestion of 40 g whey protein following whole-body resistance exercise stimulates a greater MPS response than 20 g in young resistance-trained men. However, with the current doses, the total amount of LBM does not seem to influence the response.
Language eng
DOI 10.14814/phy2.12893
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2016, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30112503

Document type: Journal Article
Collections: School of Exercise and Nutrition Sciences
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