Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice

Meakin, Paul J, Harper, Alex J, Hamilton, David Lee, Gallagher, Jennifer, McNeilly, Alison D, Burgess, Laura A, Vaanholt, Lobke M, Bannon, Kirsten A, Latcham, Judy, Hussain, Ishrut, Speakman, John R, Howlett, David R and Ashford, Michael LJ 2012, Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice, Biochemical journal, vol. 441, no. 1, pp. 285-296, doi: 10.1042/BJ20110512.

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Title Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice
Author(s) Meakin, Paul J
Harper, Alex J
Hamilton, David Lee
Gallagher, Jennifer
McNeilly, Alison D
Burgess, Laura A
Vaanholt, Lobke M
Bannon, Kirsten A
Latcham, Judy
Hussain, Ishrut
Speakman, John R
Howlett, David R
Ashford, Michael LJ
Journal name Biochemical journal
Volume number 441
Issue number 1
Start page 285
End page 296
Total pages 12
Publisher Portland Press
Place of publication London, Eng.
Publication date 2012-01
ISSN 1470-8728
Keyword(s) adiposity
amyloid precursor protein secretases
animals
aspartic acid endopeptidases
blood glucose
cell line
diet
dietary fats
gene expression regulation
glucose
insulin resistance
ion channels
mice
mice, knockout
mitochondrial proteins
myoblasts
obesity
uncoupling protein 1
science & technology
life sciences & biomedicine
biochemistry & molecular biology
beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1)
glucose uptake
insulin sensitivity
liver
skeletal muscle
uncoupling protein (UCP)
Language eng
DOI 10.1042/BJ20110512
Field of Research 06 Biological Sciences
11 Medical And Health Sciences
03 Chemical Sciences
Copyright notice ©2011, The Author(s)
Persistent URL http://hdl.handle.net/10536/DRO/DU:30112659

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