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Emblica officinalis improves glycemic status and oxidative stress in STZ induced type 2 diabetic model rats

Ansari, Aneesa, Shahriar, Md. Shahed Zaman, Hassan, Md. Mehedi, Das, Shukla Rani, Rokeya, Begum, Haque, Md. Anwarul, Haque, Md Enamul, Biswas, Nirupam and Sarkar, Tama 2014, Emblica officinalis improves glycemic status and oxidative stress in STZ induced type 2 diabetic model rats, Asian Pacific journal of tropical medicine, vol. 7, no. 1, pp. 21-25, doi: 10.1016/S1995-7645(13)60185-6.

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Title Emblica officinalis improves glycemic status and oxidative stress in STZ induced type 2 diabetic model rats
Author(s) Ansari, Aneesa
Shahriar, Md. Shahed Zaman
Hassan, Md. Mehedi
Das, Shukla Rani
Rokeya, Begum
Haque, Md. Anwarul
Haque, Md EnamulORCID iD for Haque, Md Enamul orcid.org/0000-0002-8893-2181
Biswas, Nirupam
Sarkar, Tama
Journal name Asian Pacific journal of tropical medicine
Volume number 7
Issue number 1
Start page 21
End page 25
Total pages 5
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2014-01
ISSN 1995-7645
2352-4146
Keyword(s) antidiabetic
antioxidant
Emblica officinalis
non-insulin dependent diabetes mellitus
type 2 diabetic rats
reduced glutathione
alanine transaminase
analysis of variance
animals
antioxidants
blood glucose
creatinine
diabetes mellitus, experimental
diabetes mellitus, type 2
glucose
glutathione
hypoglycemic agents
insulin
male
malondialdehyde
oxidative stress
phyllanthus emblica
plant extracts
rats
rats, Long-Evans
Summary Objective
To evaluate the antidiabetic and antioxidant potential of Emblica officinalis (E. officinalis) fruit on normal and type 2 diabetic rats.

Methods
Type 2 diabetes was induced into the male Long-Evans rats. The rats were divided into nine groups including control groups receiving water, type 2 diabetic controls, type 2 diabetic rats treated with glibenclamide (T2GT) and type 2 diabetic rats treated with aqueous extract of fruit pulp of E. officinalis. They were fed orally for 8 weeks with a single feeding. Blood was collected by cutting the tail tip on 0 and 28 days and by decapitation on 56 day. Packed red blood cells and serum were used for evaluating different biochemical parameters.

Results
Four weeks administration of aqueous extract of E. officinalis improved oral glucose tolerance in type 2 rats and after 8 weeks it caused significant (P<0.007) reduction in fasting serum glucose level compared to 0 day. Triglycerides decreased by 14% but there was no significant change in serum ALT, creatinine, cholesterol and insulin level in any group. Furthermore, reduced erythrocyte malondialdehyde level showed no significant change (P<0.07) but reduced glutathione content was found to be increased significantly (P<0.05).

Conclusions
The aqueous extract of E. officinalis has a promising antidiabetic and antioxidant properties and may be considered for further clinical studies in drug development.
Language eng
DOI 10.1016/S1995-7645(13)60185-6
Copyright notice ©2014, Elsevier
Free to Read? Yes
Use Rights Creative Commons Attribution Non-Commercial No-Derivatives licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30112676

Document type: Journal Article
Collections: School of Medicine
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.