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Skeletal muscle insulin signaling and whole-body glucose metabolism following acute sleep restriction in healthy males

Sweeney, Emma L., Jeromson, Stewart, Hamilton, D. Lee, Brooks, Naomi E. and Walshe, Ian H. 2017, Skeletal muscle insulin signaling and whole-body glucose metabolism following acute sleep restriction in healthy males, Physiological reports, vol. 5, no. 23, doi: 10.14814/phy2.13498.

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Title Skeletal muscle insulin signaling and whole-body glucose metabolism following acute sleep restriction in healthy males
Author(s) Sweeney, Emma L.
Jeromson, Stewart
Hamilton, D. Lee
Brooks, Naomi E.
Walshe, Ian H.
Journal name Physiological reports
Volume number 5
Issue number 23
Article ID e13498
Total pages 8
Publisher Wiley
Place of publication Bethesda, Md.
Publication date 2017-12
ISSN 2051-817X
Keyword(s) Glucose tolerance
PKB activity
metabolism
peripheral insulin signaling
Adolescent
Adult
Glucose
Humans
Insulin
Insulin Resistance
Male
Muscle, Skeletal
Proto-Oncogene Proteins c-akt
Signal Transduction
Sleep Deprivation
Summary Sleep restriction is associated with impaired glucose metabolism and insulin resistance, however, the underlying mechanisms leading to this impairment are unknown. This study aimed to assess whether the decrease in insulin sensitivity observed after sleep restriction is accompanied by changes in skeletal muscle PKB activity. Ten healthy young males participated in this randomized crossover study which included two conditions separated by a 3-week washout period. Participants underwent two nights of habitual sleep (CON) and two nights of sleep which was restricted to 50% of habitual sleep duration (SR) in the home environment. Whole-body glucose tolerance and insulin sensitivity were assessed by an oral glucose tolerance test after the second night of each condition. Skeletal muscle tissue samples were obtained from the vastus lateralis to determine PKB activity. Findings displayed no effect of trial on plasma glucose concentrations (P = 0.222). Plasma insulin area under the curve was higher after sleep restriction compared to the control (P = 0.013). Matsuda index was 18.6% lower in the sleep restriction (P = 0.010). Fold change in PKB activity from baseline tended to be lower in the sleep restriction condition at 30 min (P = 0.098) and 120 min (P = 0.087). In conclusion, we demonstrated decreased whole-body insulin sensitivity in healthy young males following two nights of sleep restriction. Skeletal muscle insulin signaling findings are inconclusive and require further study to examine any potential changes.
Language eng
DOI 10.14814/phy2.13498
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2017, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30112698

Document type: Journal Article
Collections: School of Exercise and Nutrition Sciences
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.