The application of microfluidic devices for viral diagnosis in developing countries

Hattersley, Samantha M., Greenman, John and Haswell, Stephen 2013, The application of microfluidic devices for viral diagnosis in developing countries, Methods in molecular biology, vol. 949, no. Microfluidic diagnostics : methods and protocols, pp. 285-303, doi: 10.1007/978-1-62703-134-9_19.


Title The application of microfluidic devices for viral diagnosis in developing countries
Author(s) Hattersley, Samantha M.
Greenman, John
Haswell, Stephen
Journal name Methods in molecular biology
Volume number 949
Issue number Microfluidic diagnostics : methods and protocols
Start page 285
End page 303
Total pages 19
Publisher Humana Press
Place of publication Totowa, N.J.
Publication date 2013
ISSN 1064-3745
1940-6029
Keyword(s) Dengue
Developing Countries
HIV Infections
Humans
Influenza, Human
Microfluidic Analytical Techniques
Virus Diseases
Summary Whilst diseases such as diabetes and cardiovascular disorders are increasing in the developed world, the main threat to global health remains viral-based infectious disease. Such diseases are notably prevalent in developing countries, where they represent a major cause of mortality; however, their detection and prevention is typically hampered by poor infrastructure and a lack of resources to support the sophisticated diagnostic tools commonly found in modern laboratories. Microfluidic-based diagnostics has the potential to close the gap between developed and developing world medical needs due to the robustness and reduced operating costs such technology offers. The most recent developments in microfluidic diagnostics for viral infections have explored the separation and enumeration of immune cells, the capture and identification of viral particles, and antiviral drug evaluation within microchannels and chambers. Advances in solid-phase separation, isothermal amplification, real-time detection of nucleotide products, and improved efficiency of detection systems in microfluidic platforms have also opened up opportunities for diagnostic innovation. This chapter reviews the potential capability microfluidic technology can offer in addressing the practical challenges of providing diagnostic technology for developing countries, illustrated by research on key viral diseases.
Language eng
DOI 10.1007/978-1-62703-134-9_19
Field of Research 0601 Biochemistry And Cell Biology
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2013, Springer Science+Business Media, LLC
Persistent URL http://hdl.handle.net/10536/DRO/DU:30112812

Document type: Journal Article
Collection: School of Life and Environmental Sciences
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