HDAC inhibition attenuates cardiac hypertrophy by acetylation and deacetylation of target genes

Ooi, Jenny Y. Y., Tuano, Natasha K., Rafehi, Haloom, Gao, Xiao-Ming, Ziemann, Mark, Du, Xiao-Jun and El-Osta, Assam 2015, HDAC inhibition attenuates cardiac hypertrophy by acetylation and deacetylation of target genes, Epigenetics, vol. 10, no. 5, pp. 418-430, doi: 10.1080/15592294.2015.1024406.

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Title HDAC inhibition attenuates cardiac hypertrophy by acetylation and deacetylation of target genes
Author(s) Ooi, Jenny Y. Y.
Tuano, Natasha K.
Rafehi, Haloom
Gao, Xiao-Ming
Ziemann, MarkORCID iD for Ziemann, Mark orcid.org/0000-0002-7688-6974
Du, Xiao-Jun
El-Osta, Assam
Journal name Epigenetics
Volume number 10
Issue number 5
Start page 418
End page 430
Total pages 13
Publisher Taylor & Francis
Place of publication Abingdon, Eng.
Publication date 2015
ISSN 1559-2308
Keyword(s) ANP, Atrial natriuretic peptide
BNP, Brain natriuretic peptide
BW, Body Weight
ChIP, Chromatin Immunoprecipitation
Ct, threshold cycle number
Cxcl10, Chemokine (C-X-C Motif) ligand 10
ENCODE, Encyclopedia of DNA Elements Consortium
FDR, False Discovery Rate
FS, Fractional Shortening
GAIIx, Genome Analyzer IIx
HDAC inhibitor
HDAC, Histone deacetylase
Icam1, Intercellular adhesion molecule 1
Il21r, Interleukin-21 receptor
Il6ra, Interleukin-6 receptor
LV, Left Ventricle
LVDd, Left Ventricular Diastolic Dimension
LVH, Left Ventricle Hypertrophy
MACs, Model-based Analysis of ChIP-seq
NES, normalized enrichment score
NFκB, Nuclear factor of kappa light polypeptide gene enhancer in B-cells
NGS, Next Generation Sequencing
SEM, Standard Error of the Mean
Serca2a, Sarcoplasmic reticulum Ca2+ ATPase
TAC veh, TAC vehicle
TAC, Transverse Aortic Constriction
TF, transcription factor
TL, Tibia Length
TSA, Trichostatin A
TSS, Transcription Start Site
Ticam2, Toll-like receptor adaptor molecule 2
Traf3, TNF receptor-associated factor 3
UTR, Untranslated region
Vcam1, Vascular cell adhesion molecule 1
cDNA, complementary DNA
cardiac hypertrophy
chromatin
epigenetics
histone acetylation
next generation sequencing
α/βMHC, Alpha/Beta myosin heavy chain
Acetylation
Animals
Aorta
Cardiomegaly
Gene Expression Regulation
Histone Deacetylase Inhibitors
Histone Deacetylases
Histones
Hydroxamic Acids
Male
Mice, Inbred C57BL
Myocardium
NF-kappa B
Science & Technology
Life Sciences & Biomedicine
Biochemistry & Molecular Biology
Genetics & Heredity
alpha/beta MHC, Alpha/Beta myosin heavy chain
C-t, threshold cycle number
NF kappa B, Nuclear factor of kappa light polypeptide gene enhancer in B-cells
NF-KAPPA-B
TRANSCRIPTION START SITES
HISTONE H3 ACETYLATION
ADVANCED HEART-FAILURE
HUMAN GENOME
PRESSURE-OVERLOAD
HYPERTENSIVE-RATS
CROSS-TALK
CLASS-I
EXPRESSION
Language eng
DOI 10.1080/15592294.2015.1024406
Field of Research 0604 Genetics
0601 Biochemistry And Cell Biology
1101 Medical Biochemistry And Metabolomics
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, Taylor & Francis Group, LLC
Persistent URL http://hdl.handle.net/10536/DRO/DU:30112917

Document type: Journal Article
Collection: School of Life and Environmental Sciences
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