Epidemiology report: trends in sex-specific cerebrovascular disease mortality in Europe based on WHO mortality data

Shah, Rushabh, Wilkins, Elizabeth, Nichols, Melanie, Kelly, Paul, El-Sadi, Farah, Wright, F. Lucy and Townsend, Nick 2018, Epidemiology report: trends in sex-specific cerebrovascular disease mortality in Europe based on WHO mortality data, European heart journal, doi: 10.1093/eurheartj/ehy378.

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Title Epidemiology report: trends in sex-specific cerebrovascular disease mortality in Europe based on WHO mortality data
Author(s) Shah, Rushabh
Wilkins, Elizabeth
Nichols, MelanieORCID iD for Nichols, Melanie orcid.org/0000-0002-7834-5899
Kelly, Paul
El-Sadi, Farah
Wright, F. Lucy
Townsend, Nick
Journal name European heart journal
Publisher Oxford University Press
Place of publication Oxford, Eng.
Publication date 2018-08-14
ISSN 0195-668X
1522-9645
Summary Aims: There have been substantial declines in cerebrovascular disease mortality across much of Europe, mirroring trends in deaths from cardiovascular disease as a whole. No study has investigated trends in cerebrovascular disease, and its subtypes within all European countries. This study aimed to examine sex-specific trends in cerebrovascular disease, and three of its sub-types: ischaemic stroke, haemorrhagic stroke, and subarachnoid haemorrhage (SAH), in Europe between 1980 and 2016. Methods and results: Sex-specific mortality data for each country of the World Health Organization (WHO) Europe region were extracted from the WHO global mortality database and analysed using Joinpoint software to examine trends. The number and location of significant joinpoints for each country by sex and subtype was determined using a log-linear model. The annual percentage change within each segment was calculated along with the average annual percentage change over the duration of all available data. The last 35 years have seen large overall declines in cerebrovascular disease mortality rates in the majority of European countries. While these declines have continued steadily in more than half of countries, this analysis has revealed evidence of recent plateauing and even increases in stroke mortality in a number of countries, in both sexes, and in all four geographical sub-regions of Europe. Analysis by stroke sub-type revealed that recent plateauing was most common for haemorraghic stroke and increases were most common for ischaemic stroke. Conclusion: These findings highlight the need for continued research into the inequalities in both current stroke mortality outcomes and trends across Europe, as well as the causes behind any recent plateauing of total cerebrovascular disease or its subtypes.
Notes In Press
Language eng
DOI 10.1093/eurheartj/ehy378
Field of Research 1102 Cardiovascular Medicine And Haematology
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2018, The Authors
Persistent URL http://hdl.handle.net/10536/DRO/DU:30112972

Document type: Journal Article
Collection: Population Health
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