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Targeting versican as a therapeutic strategy in Duchenne muscular dystrophy

McRae, Natasha 2018, Targeting versican as a therapeutic strategy in Duchenne muscular dystrophy, Ph.D thesis, School of Medicine, Deakin University.

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Title Targeting versican as a therapeutic strategy in Duchenne muscular dystrophy
Author McRae, Natasha
Institution Deakin University
School School of Medicine
Faculty Faculty of Health
Degree type Research doctorate
Degree name Ph.D
Thesis advisor Stanford, Nicole
Date submitted 2018-08-09
Summary Fibrosis drives muscle degeneration and weakness in Duchenne muscular dystrophy. This thesis identified versican as an important fibrosis-associated protein overexpressed in dystrophic muscles, with cellular expression reduced by glucocorticoids. Using novel mouse models, the importance of versican reduction in improving the contractile function of dystrophic muscles was also established.
Language eng
Field of Research 111601 Cell Physiology
110799 Immunology not elsewhere classified
110106 Medical Biochemistry: Proteins and Peptides (incl Medical Proteomics)
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
Description of original 265 p.
Copyright notice ┬ęThe author
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30113099

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Created: Mon, 03 Sep 2018, 16:32:14 EST by Bayne Christine

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.