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A portable sensor for cell optical density measurement in microfluidic chips

Alam, Muhd Nazrul Hisham Zainal, Jaya Kumar, Jayanth, John Whyte, Daniel, Doeven, Egan H and Kouzani, Abbas 2018, A portable sensor for cell optical density measurement in microfluidic chips, Measurement and control, vol. 51, no. 7-8, pp. 213-222, doi: 10.1177/0020294018783440.

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Title A portable sensor for cell optical density measurement in microfluidic chips
Author(s) Alam, Muhd Nazrul Hisham Zainal
Jaya Kumar, Jayanth
John Whyte, Daniel
Doeven, Egan HORCID iD for Doeven, Egan H orcid.org/0000-0003-2677-4269
Kouzani, AbbasORCID iD for Kouzani, Abbas orcid.org/0000-0002-6292-1214
Journal name Measurement and control
Volume number 51
Issue number 7-8
Start page 213
End page 222
Total pages 10
Publisher SAGE Publications
Place of publication London, Eng.
Publication date 2018-09-01
ISSN 0020-2940
Keyword(s) cell optical density
miniaturization
smartphone-controlled
device
sensor
microfluidic
Summary This paper presents the development of a smartphone-controlled wireless device for cell optical density sensing in microfluidic chips. The footprint of the device is very compact relative to a classical laboratory spectrophotometer, making it a portable device. The cell optical density sensing device consists of an embedded microcontroller, optical sensing components, and a wireless transceiver performing cell optical density measurements in disposable microfluidic chips fabricated from poly(methylmethacrylate) polymers. The device is controlled by an Android application allowing for true portability and the possibility of remote or field operation of the device. The use of microfluidic chips as the sample carrier for optical density detection instead of a plastic cuvette allows users the flexibility to explore and/or conduct a variety of micro-scale chemical analysis using the device which would be difficult in a cuvette-based system. The function of the device is validated through a series of off-line and online optical density measurements using Saccharomyces cerevisae yeast cultures. The device is low cost, small enough to fit in most laboratory flow hood cabinets, and can be easily integrated into miniature bioreactor systems. Moreover, wireless communication enables the user to operate the device using smartphones or rapidly transfer the measured data to an online repository for analysis or storage.
Language eng
DOI 10.1177/0020294018783440
Copyright notice ©2018, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30113238

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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.