Dengue virus infection changes Aedes aegypti oviposition olfactory preferences

Gaburro, Julie, Paradkar, Prasad N, Klein, Melissa, Bhatti, Asim, Nahavandi, Saeid and Duchemin, Jean-Bernard 2018, Dengue virus infection changes Aedes aegypti oviposition olfactory preferences, Scientific reports, vol. 8, pp. 1-11, doi: 10.1038/s41598-018-31608-x.

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Title Dengue virus infection changes Aedes aegypti oviposition olfactory preferences
Author(s) Gaburro, JulieORCID iD for Gaburro, Julie orcid.org/0000-0001-6609-6429
Paradkar, Prasad N
Klein, Melissa
Bhatti, AsimORCID iD for Bhatti, Asim orcid.org/0000-0001-6876-1437
Nahavandi, SaeidORCID iD for Nahavandi, Saeid orcid.org/0000-0002-0360-5270
Duchemin, Jean-Bernard
Journal name Scientific reports
Volume number 8
Article ID 13179
Start page 1
End page 11
Total pages 11
Publisher Nature Publishing Group
Place of publication London, Eng.
Publication date 2018-09-04
ISSN 2045-2322
Keyword(s) Aedes aegypti mosquitoes
Flaviviruses
Olfactory learning
Science & technology
Summary Aedes aegypti mosquitoes, main vectors for numerous flaviviruses, have olfactory preferences and are capable of olfactory learning especially when seeking their required environmental conditions to lay their eggs. In this study, we showed that semiochemical conditions during Aedes aegypti larval rearing affected future female choice for oviposition: water-reared mosquitoes preferred to lay eggs in water or p-cresol containers, while skatole reared mosquitoes preferred skatole sites. Using two independent behavioural assays, we showed that this skatole preference was lost in mosquitoes infected with dengue virus. Viral RNA was extracted from infected female mosquito heads, and an increase of virus load was detected from 3 to 10 days post infection, indicating replication in the insect head and possibly in the central nervous system. Expression of selected genes, potentially implied in olfactory learning processes, were also altered during dengue infection. Based on these results, we hypothesise that dengue virus infection alters gene expression in the mosquito's head and is associated with a loss of olfactory preferences, possibly modifying oviposition site choice of female mosquitoes.
Language eng
DOI 10.1038/s41598-018-31608-x
Field of Research 090609 Signal Processing
060102 Bioinformatics
090303 Biomedical Instrumentation
100402 Medical Biotechnology Diagnostics (incl Biosensors)
110902 Cellular Nervous System
080109 Pattern Recognition and Data Mining
Socio Economic Objective 970109 Expanding Knowledge in Engineering
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2018, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30113250

Document type: Journal Article
Collections: Centre for Intelligent Systems Research
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Created: Mon, 10 Sep 2018, 14:00:33 EST

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