Granulocyte colony-stimulating factor and its potential application for skeletal muscle repair and regeneration

Wright, Craig, Ward, Alister and Russell, Aaron 2017, Granulocyte colony-stimulating factor and its potential application for skeletal muscle repair and regeneration, Mediators of inflammation, vol. 2017, pp. 1-9, doi: 10.1155/2017/7517350.

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Title Granulocyte colony-stimulating factor and its potential application for skeletal muscle repair and regeneration
Author(s) Wright, CraigORCID iD for Wright, Craig orcid.org/0000-0001-7903-3144
Ward, AlisterORCID iD for Ward, Alister orcid.org/0000-0001-7945-7975
Russell, AaronORCID iD for Russell, Aaron orcid.org/0000-0002-7323-9501
Journal name Mediators of inflammation
Volume number 2017
Article ID 7517350
Start page 1
End page 9
Total pages 9
Publisher Hindawi Publishing Corporation
Place of publication Cairo, Egypt
Publication date 2017-12-07
ISSN 1466-1861
Keyword(s) Animals
Granulocyte Colony-Stimulating Factor
Humans
Muscle, Skeletal
Muscular Diseases
Phosphatidylinositol 3-Kinases
Receptors, Granulocyte Colony-Stimulating Factor
Regeneration
Signal Transduction
Science & Technology
Life Sciences & Biomedicine
Cell Biology
Immunology
FACTOR G-CSF
SPINAL-CORD-INJURY
PROGENITOR-CELL MOBILIZATION
ACUTE MYOCARDIAL-INFARCTION
ACUTE ISCHEMIC-STROKE
FACTOR-RECEPTOR
IN-VIVO
MYOBLAST PROLIFERATION
NEUROPROTECTIVE THERAPY
COMPRESSION MYELOPATHY
Summary Granulocyte colony-stimulating factor (G-CSF) was originally discovered in the context of hematopoiesis. However, the identification of the G-CSF receptor (G-CSFR) being expressed outside the hematopoietic system has revealed wider roles for G-CSF, particularly in tissue repair and regeneration. Skeletal muscle damage, including that following strenuous exercise, induces an elevation in plasma G-CSF, implicating it as a potential mediator of skeletal muscle repair. This has been supported by preclinical studies and clinical trials investigating G-CSF as a potential therapeutic agent in relevant disease states. This review focuses on the growing literature associated with G-CSF and G-CSFR in skeletal muscle under healthy and disease conditions and highlights the current controversies.
Language eng
DOI 10.1155/2017/7517350
Field of Research 1107 Immunology
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Persistent URL http://hdl.handle.net/10536/DRO/DU:30113550

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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