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Dietary cows' milk protein A1 beta-casein increases the incidence of T1D in NOD mice

Chia, Joanne S. J., McRae, Jennifer L., Enjapoori, Ashwantha Kumar, Lefèvre, Christophe M., Kukuljan, Sonja and Dwyer, Karen M. 2018, Dietary cows' milk protein A1 beta-casein increases the incidence of T1D in NOD mice, Nutrients, vol. 10, no. 9, doi: 10.3390/nu10091291.

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Title Dietary cows' milk protein A1 beta-casein increases the incidence of T1D in NOD mice
Author(s) Chia, Joanne S. J.
McRae, Jennifer L.
Enjapoori, Ashwantha Kumar
Lefèvre, Christophe M.
Kukuljan, Sonja
Dwyer, Karen M.ORCID iD for Dwyer, Karen M. orcid.org/0000-0002-4376-9720
Journal name Nutrients
Volume number 10
Issue number 9
Article ID 1291
Total pages 15
Publisher MDPI Publishing
Place of publication Basel, Switzerland
Publication date 2018-09-12
ISSN 2072-6643
Keyword(s) NOD mice
beta-casein
cows’ milk
epigenetics
type 1 diabetes
Summary The contribution of cows' milk containing beta-casein protein A1 variant to the development of type 1 diabetes (T1D) has been controversial for decades. Despite epidemiological data demonstrating a relationship between A1 beta-casein consumption and T1D incidence, direct evidence is limited. We demonstrate that early life exposure to A1 beta-casein through the diet can modify progression to diabetes in non-obese diabetic (NOD) mice, with the effect apparent in later generations. Adult NOD mice from the F0 generation and all subsequent generations (F1 to F4) were fed either A1 or A2 beta-casein supplemented diets. Diabetes incidence in F0⁻F2 generations was similar in both cohorts of mice. However, diabetes incidence doubled in the F3 generation NOD mice fed an A1 beta-casein supplemented diet. In F4 NOD mice, subclinical insulitis and altered glucose handling was evident as early as 10 weeks of age in A1 fed mice only. A significant decrease in the proportion of non-conventional regulatory T cell subset defined as CD4⁺CD25-FoxP3⁺ was evident in the F4 generation of A1 fed mice. This feeding intervention study demonstrates that dietary A1 beta-casein may affect glucose homeostasis and T1D progression, although this effect takes generations to manifest.
Language eng
DOI 10.3390/nu10091291
Field of Research 1111 Nutrition And Dietetics
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2018, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30114008

Document type: Journal Article
Collections: School of Medicine
Open Access Collection
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.