Preexercise breakfast ingestion versus extended overnight fasting increases postprandial glucose flux after exercise in healthy men

Edinburgh, Robert M., Hengist, Aaron, Smith, Harry A., Travers, Rebecca L., Koumanov, Francoise, Betts, James A., Thompson, Dylan, Walhin, Jean-Philippe, Wallis, Gareth A., Hamilton, D. Lee, Stevenson, Emma J., Tipton, Kevin D. and Gonzalez, Javier T. 2018, Preexercise breakfast ingestion versus extended overnight fasting increases postprandial glucose flux after exercise in healthy men, American journal of physiology endocrinology and metabolism, vol. 315, no. 5, pp. E1062-E1074, doi: 10.1152/ajpendo.00163.2018.

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Title Preexercise breakfast ingestion versus extended overnight fasting increases postprandial glucose flux after exercise in healthy men
Author(s) Edinburgh, Robert M.
Hengist, Aaron
Smith, Harry A.
Travers, Rebecca L.
Koumanov, Francoise
Betts, James A.
Thompson, Dylan
Walhin, Jean-Philippe
Wallis, Gareth A.
Hamilton, D. LeeORCID iD for Hamilton, D. Lee orcid.org/0000-0002-5620-4788
Stevenson, Emma J.
Tipton, Kevin D.
Gonzalez, Javier T.
Journal name American journal of physiology endocrinology and metabolism
Volume number 315
Issue number 5
Start page E1062
End page E1074
Total pages 13
Publisher American Physiological Society
Place of publication Bethesda, Md.
Publication date 2018-11-01
ISSN 1522-1555
Keyword(s) breakfast
exercise
glycemia
insulin sensitivity
metabolism
Science & Technology
Life Sciences & Biomedicine
Endocrinology & Metabolism
Physiology
ADIPOSE-TISSUE
CARBOHYDRATE INGESTION
GLYCEMIC INDEX
2ND-MEAL PHENOMENON
ENERGY-BALANCE
FATTY-ACIDS
FOOD-INTAKE
MEAL
Summary The aim of this study was to characterize postprandial glucose flux after exercise in the fed versus overnight fasted state and to investigate the potential underlying mechanisms. In a randomized order, twelve men underwent breakfast-rest [(BR) 3 h semirecumbent], breakfast-exercise [(BE) 2 h semirecumbent before 60 min of cycling (50% peak power output)], and overnight fasted exercise [(FE) as per BE omitting breakfast] trials. An oral glucose tolerance test (OGTT) was completed after exercise (after rest on BR). Dual stable isotope tracers ([U-13C] glucose ingestion and [6,6-2H2] glucose infusion) and muscle biopsies were combined to assess postprandial plasma glucose kinetics and intramuscular signaling, respectively. Plasma intestinal fatty acid binding (I-FABP) concentrations were determined as a marker of intestinal damage. Breakfast before exercise increased postexercise plasma glucose disposal rates during the OGTT, from 44 g/120 min in FE {35 to 53 g/120 min [mean (normalized 95% confidence interval)] to 73 g/120 min in BE [55 to 90 g/120 min; P = 0.01]}. This higher plasma glucose disposal rate was, however, offset by increased plasma glucose appearance rates (principally OGTT-derived), resulting in a glycemic response that did not differ between BE and FE ( P = 0.11). Plasma I-FABP concentrations during exercise were 264 pg/ml (196 to 332 pg/ml) lower in BE versus FE ( P = 0.01). Breakfast before exercise increases postexercise postprandial plasma glucose disposal, which is offset (primarily) by increased appearance rates of orally ingested glucose. Therefore, metabolic responses to fed-state exercise cannot be readily inferred from studies conducted in a fasted state.
Language eng
DOI 10.1152/ajpendo.00163.2018
Field of Research 06 Biological Sciences
11 Medical And Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2019, American Physiological Society
Persistent URL http://hdl.handle.net/10536/DRO/DU:30114675

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