RNA structure- a neglected puppet master for the evolution of virus and host immunity

Smyth, Redmond P., Negroni, Matteo, Lever, Andrew M., Mak, Johnson and Kenyon, Julia C. 2018, RNA structure- a neglected puppet master for the evolution of virus and host immunity, Frontiers in Immunology, vol. 9, doi: 10.3389/fimmu.2018.02097.

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Title RNA structure- a neglected puppet master for the evolution of virus and host immunity
Author(s) Smyth, Redmond P.
Negroni, Matteo
Lever, Andrew M.
Mak, JohnsonORCID iD for Mak, Johnson orcid.org/0000-0002-5229-5707
Kenyon, Julia C.
Journal name Frontiers in Immunology
Volume number 9
Article ID 2097
Total pages 7
Publisher Frontiers Media
Place of publication Lausanne, Switzerland
Publication date 2018-09-19
ISSN 1664-3224
Keyword(s) RNA structure
immune evasion
secondary structure
viral RNA
viral evolution
Science & Technology
Life Sciences & Biomedicine
Immunology
HIV-1 INTERSUBTYPE RECOMBINATION
IN-VIVO
NONCODING RNAS
NMR DETECTION
HOT-SPOTS
GENOME
REVEALS
GENE
CELLS
Summary The central dogma of molecular biology describes the flow of genetic information from DNA to protein via an RNA intermediate. For many years, RNA has been considered simply as a messenger relaying information between DNA and proteins. Recent advances in next generation sequencing technology, bioinformatics, and non-coding RNA biology have highlighted the many important roles of RNA in virtually every biological process. Our understanding of RNA biology has been further enriched by a number of significant advances in probing RNA structures. It is now appreciated that many cellular and viral biological processes are highly dependent on specific RNA structures and/or sequences, and such reliance will undoubtedly impact on the evolution of both hosts and viruses. As a contribution to this special issue on host immunity and virus evolution, it is timely to consider how RNA sequences and structures could directly influence the co-evolution between hosts and viruses. In this manuscript, we begin by stating some of the basic principles of RNA structures, followed by describing some of the critical RNA structures in both viruses and hosts. More importantly, we highlight a number of available new tools to predict and to evaluate novel RNA structures, pointing out some of the limitations readers should be aware of in their own analyses.
Language eng
DOI 10.3389/fimmu.2018.02097
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2018, Smyth, Negroni, Lever, Mak and Kenyon
Persistent URL http://hdl.handle.net/10536/DRO/DU:30114698

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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