A comparison of urinary mercury between children with autism spectrum disorders and control children

Wright, Barry, Pearce, Helen, Allgar, Victoria, Miles, Jeremy, Whitton, Clare, Leon, Irene, Jardine, Jenny, McCaffrey, Nicola, Smith, Rob, Holbrook, Ian, Lewis, John, Goodall, David and Alderson-Day, Ben 2012, A comparison of urinary mercury between children with autism spectrum disorders and control children, PLOS one, vol. 7, no. 2, pp. 1-6, doi: 10.1371/journal.pone.0029547.

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Title A comparison of urinary mercury between children with autism spectrum disorders and control children
Author(s) Wright, Barry
Pearce, Helen
Allgar, Victoria
Miles, Jeremy
Whitton, Clare
Leon, Irene
Jardine, Jenny
McCaffrey, NicolaORCID iD for McCaffrey, Nicola orcid.org/0000-0003-3684-3723
Smith, Rob
Holbrook, Ian
Lewis, John
Goodall, David
Alderson-Day, Ben
Journal name PLOS one
Volume number 7
Issue number 2
Article ID e29547
Start page 1
End page 6
Total pages 6
Publisher Public Library of Science (PLoS)
Place of publication San Francisco, Calif.
Publication date 2012
ISSN 1932-6203
Keyword(s) Case-Control Studies
Child
Child Development Disorders, Pervasive
Cohort Studies
Creatinine
Female
Follow-Up Studies
Humans
Male
Mass Spectrometry
Mercury
Prognosis
Summary BACKGROUND: Urinary mercury concentrations are used in research exploring mercury exposure. Some theorists have proposed that autism is caused by mercury toxicity. We set out to test whether mercury concentrations in the urine of children with autism were significantly increased or decreased compared to controls or siblings. METHODS: Blinded cohort analyses were carried out on the urine of 56 children with autism spectrum disorders (ASD) compared to their siblings (n = 42) and a control sample of children without ASD in mainstream (n = 121) and special schools (n = 34). RESULTS: There were no statistically significant differences in creatinine levels, in uncorrected urinary mercury levels or in levels of mercury corrected for creatinine, whether or not the analysis is controlled for age, gender and amalgam fillings. CONCLUSIONS: This study lends no support for the hypothesis of differences in urinary mercury excretion in children with autism compared to other groups. Some of the results, however, do suggest further research in the area may be warranted to replicate this in a larger group and with clear measurement of potential confounding factors.
Language eng
DOI 10.1371/journal.pone.0029547
Field of Research MD Multidisciplinary
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2012, Wright et al.
Persistent URL http://hdl.handle.net/10536/DRO/DU:30115551

Document type: Journal Article
Collections: School of Health and Social Development
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