Functional role of amyloid β42 in systemic glucose metabolism

Czeczor, Juliane K. 2018, Functional role of amyloid β42 in systemic glucose metabolism, Ph.D thesis, School of Medicine, Deakin University.

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Title Functional role of amyloid β42 in systemic glucose metabolism
Author Czeczor, Juliane K.
Institution Deakin University
School School of Medicine
Faculty Faculty of Health
Degree type Research doctorate
Degree name Ph.D
Thesis advisor McGee, SeanORCID iD for McGee, Sean orcid.org/0000-0001-6953-106X
Date submitted 2018-11-13
Summary This thesis dealt with the functional investigation of Amyloid beta (Ab) 42 and its role in whole body glucose homeostasis, a protein otherwise known from Alzheimer's Disease. This research presented novel data on Ab42 being secreted from diabetic mouse fat pads, linking obesity to increased systemic levels of Ab42. Additionally, Ab42 administration in mice caused cardiovascular events, i.e. morphological and functional changes. In a mouse knockout model where Ab42 was removed, mice presented with a strong phenotype associated with various metabolic disturbances, supporting a crucial role for Ab42 in whole body metabolism.
Language eng
Field of Research 110306 Endocrinology
Socio Economic Objective 920104 Diabetes
Description of original 181 p.
Copyright notice ©The author
Persistent URL http://hdl.handle.net/10536/DRO/DU:30115798

Document type: Thesis
Collections: School of Medicine
Higher degree theses (citation only)
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Created: Wed, 28 Nov 2018, 14:06:10 EST by Bayne Christine

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