Body, Brain, Life for Cognitive Decline (BBL-CD): protocol for a multidomain dementia risk reduction randomized controlled trial for subjective cognitive decline and mild cognitive impairment

McMaster, Mitchell, Kim, Sarang, Clare, Linda, Torres, Susan J, D'Este, Catherine and Anstey, Kaarin J 2018, Body, Brain, Life for Cognitive Decline (BBL-CD): protocol for a multidomain dementia risk reduction randomized controlled trial for subjective cognitive decline and mild cognitive impairment, Clinical interventions in aging, vol. 13, pp. 2397-2406, doi: 10.2147/CIA.S182046.

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Title Body, Brain, Life for Cognitive Decline (BBL-CD): protocol for a multidomain dementia risk reduction randomized controlled trial for subjective cognitive decline and mild cognitive impairment
Author(s) McMaster, Mitchell
Kim, Sarang
Clare, Linda
Torres, Susan JORCID iD for Torres, Susan J orcid.org/0000-0002-2599-1934
D'Este, Catherine
Anstey, Kaarin J
Journal name Clinical interventions in aging
Volume number 13
Start page 2397
End page 2406
Total pages 10
Publisher Dovepress
Place of publication Macclesfield, Eng.
Publication date 2018
ISSN 1178-1998
Keyword(s) dementia prevention
dementia risk reduction
secondary prevention
Alzheimer’s disease
subjective cognitive decline
mild cognitive impairment
multidomain lifestyle intervention
aged
cognition
cognitive dysfunction
dementia
diet
exercise
health behavior
humans
life style
motivation
quality of life
risk factors
risk reduction behavior
science & technology
life sciences & biomedicine
geriatrics & gerontology
Summary Background: With no cure for dementia and the number of people living with the condition predicted to rapidly rise, there is an urgent need for dementia risk reduction and prevention interventions. Modifiable lifestyle risk factors have been identified as playing a major role in the development of dementia; hence, interventions addressing these risk factors represent a significant opportunity to reduce the number of people developing dementia. Relatively few interventions have been trialed in older participants with cognitive decline (secondary prevention). Objectives: This study evaluates the efficacy and feasibility of a multidomain lifestyle risk reduction intervention for people with subjective cognitive decline (SCD) and mild cognitive impairment (MCI). Methods: This study is an 8-week, two-arm, single-blind, randomized controlled trial (RCT) of a lifestyle modification program to reduce dementia risk. The active control group receives the following four online educational modules: dementia literacy and lifestyle risk, Mediterranean diet (MeDi), cognitive engagement and physical activity. The intervention group also completes the same educational modules but receives additional practical components including sessions with a dietitian, online brain training and sessions with an exercise physiologist to assist with lifestyle modification. Results: Primary outcome measures are cognition (The Alzheimer's Disease Assessment Scale-Cognitive-Plus [ADAS-Cog-Plus]) and a composite lifestyle risk factor score for Alzheimer's disease (Australian National University - Alzheimer's Disease Risk Index [ANU-ADRI]). Secondary outcome measures are motivation to change lifestyle (Motivation to Change Lifestyle and Health Behaviour for Dementia Risk Reduction [MCLHB-DRR]) and health-related quality of life (36-item Short Form Health Survey [SF-36]). Feasibility will be determined through adherence to diet (Mediterranean Diet Adherence Screener [MEDAS] and Australian Recommended Food Score [ARFS]), cognitive engagement (BrainHQ-derived statistics) and physical activity interventions (physical activity calendars). Outcomes are measured at baseline, immediately post-intervention and at 3- and 6-month follow-up by researchers blind to group allocation. Discussion: If successful and feasible, secondary prevention lifestyle interventions could provide a targeted, cost-effective way to reduce the number of people with cognitive decline going on to develop Alzheimer's disease (AD) and other dementias.
Language eng
DOI 10.2147/CIA.S182046
Field of Research 1103 Clinical Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2018, McMaster et al.
Persistent URL http://hdl.handle.net/10536/DRO/DU:30116059

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