Protocol for a single-centre, parallel-arm, double-blind randomised trial evaluating the effects of tourniquet use in total knee arthroplasty on intra-operative and post-operative outcomes

Page, Richard S., Williams, Simon, Selvaratnam, Avanthi, Waring, Shaun, Conroy, Myles, Thomson, Andrew, Beattie, Sally, Ganeshalingam, Rekha and Gill, Stephen D. 2018, Protocol for a single-centre, parallel-arm, double-blind randomised trial evaluating the effects of tourniquet use in total knee arthroplasty on intra-operative and post-operative outcomes, BMC musculoskeletal disorders, vol. 19, pp. 1-7, doi: 10.1186/s12891-018-2352-8.

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Title Protocol for a single-centre, parallel-arm, double-blind randomised trial evaluating the effects of tourniquet use in total knee arthroplasty on intra-operative and post-operative outcomes
Author(s) Page, Richard S.ORCID iD for Page, Richard S. orcid.org/0000-0002-2225-7144
Williams, Simon
Selvaratnam, Avanthi
Waring, Shaun
Conroy, Myles
Thomson, Andrew
Beattie, Sally
Ganeshalingam, Rekha
Gill, Stephen D.
Journal name BMC musculoskeletal disorders
Volume number 19
Article ID 435
Start page 1
End page 7
Total pages 7
Publisher BMC
Place of publication London, Eng.
Publication date 2018-12
ISSN 1471-2474
1471-2474
Keyword(s) Knee arthroplasty
Knee pain
Quadriceps strength
Tourniquet
Science & Technology
Life Sciences & Biomedicine
Orthopedics
Rheumatology
STRENGTH
RATES
HIP
RECOVERY
ATROPHY
DAMAGE
Summary BACKGROUND: Tourniquet use during total knee replacement is common, yet uncertainty exists regarding its benefits and harms. The primary aim of the current study is to investigate whether tourniquet use during total knee replacement leads to greater reduction in quadriceps strength than non-tourniquet use at three months post-surgery. Secondary aims include investigating the effects of tourniquet use on: quadriceps strength at day 2 and 5, and 12 months post-surgery; pain and analgesia requirements; self-reported physical function and quality of life; blood loss and replacement; surgeon satisfaction with the intra-operative visual field; operation and anaesthetic time; complications; cement mantle quality; patient satisfaction; and hospital length of stay. METHODS: The study is a single centre, parallel-arm, double-blind (participant and assessor), randomised trial with 1:1 random allocation. Participants will be undergo total knee replacement with or without tourniquet. Linear mixed models will be used for group comparisons of continuous outcomes available at multiple timepoints. Other continuous outcomes that are assessed at baseline and once/twice at follow-up will be analysed using linear regression. Categorical outcomes will be analysed using logistic regression models. DISCUSSION: This study will provide high-quality evidence regarding the effects of tourniquet use during total knee replacement, which can be used to inform surgeon decision-making. 
Language eng
DOI 10.1186/s12891-018-2352-8
Field of Research 1103 Clinical Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2018, The Author(s)
Persistent URL http://hdl.handle.net/10536/DRO/DU:30116264

Document type: Journal Article
Collections: School of Medicine
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