How is the evolution of tumour resistance at organ-scale impacted by the importance of the organ for fitness?

Gidoin, Cindy, Ujvari, Beata, Thomas, Frederic and Roche, Benjamin 2018, How is the evolution of tumour resistance at organ-scale impacted by the importance of the organ for fitness?, BMC evolutionary biology, vol. 18, pp. 1-10, doi: 10.1186/s12862-018-1298-7.

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Title How is the evolution of tumour resistance at organ-scale impacted by the importance of the organ for fitness?
Author(s) Gidoin, Cindy
Ujvari, BeataORCID iD for Ujvari, Beata
Thomas, Frederic
Roche, Benjamin
Journal name BMC evolutionary biology
Volume number 18
Article ID 185
Start page 1
End page 10
Total pages 10
Publisher BMC
Place of publication London, Eng.
Publication date 2018-12
ISSN 1471-2148
Keyword(s) Cancer risk
Biological Evolution
Computer Simulation
Models, Biological
Neoplasm Metastasis
Organ Specificity
Science & Technology
Life Sciences & Biomedicine
Evolutionary Biology
Genetics & Heredity
Summary BACKGROUND: A strong variability in cancer incidence is observed between human organs. Recently, it has been suggested that the relative contribution of organs to organism fitness (reproduction or survival) could explain at least a part of the observed variation. The objective of this study is to investigate theoretically the main factors driving the evolution of tumour resistance mechanisms of organs when their relative contribution to organism fitness is considered. We use a population-scale model where individuals can develop a tumour in a key organ (i.e. in which even a small tumour can negatively impact organism fitness), an auxiliary organ (i.e. in which only a large tumour has a relatively significant impact) or both organs because of metastasis. RESULTS: Our simulations show that natural selection acts in two different ways to prevent cancer in a key and an auxiliary organs. In the key organ, the strategy mostly selected is the highest resistance and only a high cost of resistance mitigates this behavior. Inversely, we observe that a low resistance strategy can be selected in the auxiliary organ when the development of the tumour is slow and the effect of a large tumour on the mortality of the organism is relatively weak. Nevertheless, if the tumour can spread to a key organ, higher resistance strategies are selected in the auxiliary organ. CONCLUSION: Finally, our study demonstrates that the relative contribution of organs to the organism fitness and the metastatic propensity of the tumour influence the evolution of tumour resistance at organ scale and should be considered by studies aiming to explain the variability in cancer incidence at organ-scale.
Language eng
DOI 10.1186/s12862-018-1298-7
Field of Research 0603 Evolutionary Biology
0604 Genetics
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2018, The Author(s)
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