Novel self-assembling conjugates as vectors for agrochemical delivery

Nadiminti, Pavani, Liu, Qingtao, Vanjari, Lavanya K., Dong, Yao D., Boyd, Ben J. and Cahill, David 2018, Novel self-assembling conjugates as vectors for agrochemical delivery, Journal of nanobiotechnology, vol. 16, no. 1, doi: 10.1186/s12951-018-0423-5.

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Title Novel self-assembling conjugates as vectors for agrochemical delivery
Author(s) Nadiminti, Pavani
Liu, Qingtao
Vanjari, Lavanya K.
Dong, Yao D.
Boyd, Ben J.
Cahill, DavidORCID iD for Cahill, David orcid.org/0000-0002-2556-0528
Journal name Journal of nanobiotechnology
Volume number 16
Issue number 1
Article ID 94
Total pages 15
Publisher BioMed Central
Place of publication London, Eng.
Publication date 2018-11-21
ISSN 1477-3155
Keyword(s) Arabidopsis thaliana
Herbicides
Picloram
Self-assembly
Surfactants
Weeds
Science & Technology
Life Sciences & Biomedicine
Biotechnology & Applied Microbiology
Nanoscience & Nanotechnology
Science & Technology - Other Topics
LIQUID-CRYSTALLINE PARTICLES
AUXIN HERBICIDES
DRUG-DELIVERY
NANOPARTICLES
SURFACES
POLYMER
NANOSTRUCTURE
PHYTANTRIOL
ADSORPTION
Summary BACKGROUND: Modern agricultural practises rely on surfactant-based spray applications to eliminate weeds in crops. The wide spread and indiscriminate use of surfactants may result in a number of deleterious effects that are not limited to impacts on the crop and surrounding farm eco-system but include effects on human health. To provide a safer alternative to the use of surfactant-based formulations, we have synthesised a novel, self-assembling herbicide conjugate for the delivery of a broad leaf herbicide, picloram. RESULTS: The synthesized self-assembling amphiphile-picloram (SAP) conjugate has three extending arms: a lipophilic lauryl chain, a hydrophilic polyethylene glycol chain and the amphiphobic agrochemical active picloram. We propose that the SAP conjugate maintains its colloidal stability by quickly transitioning between micellar and inverse micellar phases in hydrophilic and lipophilic environments respectively. The SAP conjugate provides the advantage of a phase structure that enables enhanced interaction with the hydrophobic epicuticular wax surface of the leaf. We have investigated the herbicidal efficiency of the SAP conjugate compared against that of commercial picloram formulations using the model plant Arabidopsis thaliana and found that when tested at agriculturally relevant doses between 0.58 and 11.70 mM a dose-dependent herbicidal effect with comparable kill rates was evident. CONCLUSION: Though self-assembling drug carriers are not new to the pharmaceutical industry their use for the delivery of agrochemicals shows great promise but is largely unexplored. We have shown that SAP may be used as an alternative to current surfactant-based agrochemical formulations and has the potential to shift present practises towards a more sustainable approach.
Language eng
DOI 10.1186/s12951-018-0423-5
Field of Research 10 Technology
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2018, The Authors
Persistent URL http://hdl.handle.net/10536/DRO/DU:30116285

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