Improving metabolic health in obese male mice via diet and exercise restores embryo development and fetal growth

McPherson, Nicole O., Bakos, Hassan W., Owens, Julie A., Setchell, Brian P. and Lane, Michelle 2013, Improving metabolic health in obese male mice via diet and exercise restores embryo development and fetal growth, PLoS One, vol. 8, no. 8, pp. 1-10, doi: 10.1371/journal.pone.0071459.

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Title Improving metabolic health in obese male mice via diet and exercise restores embryo development and fetal growth
Author(s) McPherson, Nicole O.
Bakos, Hassan W.
Owens, Julie A.ORCID iD for Owens, Julie A. orcid.org/0000-0002-7498-1353
Setchell, Brian P.
Lane, Michelle
Journal name PLoS One
Volume number 8
Issue number 8
Article ID e71459
Start page 1
End page 10
Total pages 10
Publisher Public Library of Science (PLoS)
Place of publication San Francisco, Calif.
Publication date 2013-08
ISSN 1932-6203
Keyword(s) Animals
Cadherins
Cell Communication
Cell Count
DNA Damage
Diet
Embryonic Development
Female
Fetal Development
Fetus
Germ Layers
Hormones
Male
Mice
Mice, Inbred C57BL
Mice, Obese
Physical Conditioning, Animal
Staining and Labeling
Trophoblasts
Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
BODY-MASS INDEX
ASSISTED REPRODUCTIVE TECHNOLOGY
HIGH-FAT DIET
HUMAN SPERMATOZOA
DNA-DAMAGE
OXIDATIVE STRESS
MALE-INFERTILITY
SPERM FUNCTION
MOUSE EMBRYO
WEIGHT-LOSS
Summary Paternal obesity is now clearly associated with or causal of impaired embryo and fetal development and reduced pregnancy rates in humans and rodents. This appears to be a result of reduced blastocyst potential. Whether these adverse embryo and fetal outcomes can be ameliorated by interventions to reduce paternal obesity has not been established. Here, male mice fed a high fat diet (HFD) to induce obesity were used, to determine if early embryo and fetal development is improved by interventions of diet (CD) and/or exercise to reduce adiposity and improve metabolism. Exercise and to a lesser extent CD in obese males improved embryo development rates, with increased cell to cell contacts in the compacting embryo measured by E-cadherin in exercise interventions and subsequently, increased blastocyst trophectoderm (TE), inner cell mass (ICM) and epiblast cell numbers. Implantation rates and fetal development from resulting blastocysts were also improved by exercise in obese males. Additionally, all interventions to obese males increased fetal weight, with CD alone and exercise alone, also increasing fetal crown-rump length. Measures of embryo and fetal development correlated with paternal measures of glycaemia, insulin action and serum lipids regardless of paternal adiposity or intervention, suggesting a link between paternal metabolic health and subsequent embryo and fetal development. This is the first study to show that improvements to metabolic health of obese males through diet and exercise can improve embryo and fetal development, suggesting such interventions are likely to improve offspring health.
Language eng
DOI 10.1371/journal.pone.0071459
Field of Research MD Multidisciplinary
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2013 McPherson et al.
Persistent URL http://hdl.handle.net/10536/DRO/DU:30116330

Document type: Journal Article
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