Paternal under-nutrition programs metabolic syndrome in offspring which can be reversed by antioxidant/vitamin food fortification in fathers

McPherson, Nicole O., Fullston, Tod, Kang, Wan Xian, Sandeman, Lauren Y., Corbett, Mark A., Owens, Julie A. and Lane, Michelle 2016, Paternal under-nutrition programs metabolic syndrome in offspring which can be reversed by antioxidant/vitamin food fortification in fathers, Scientific reports, vol. 6, pp. 1-14, doi: 10.1038/srep27010.

Attached Files
Name Description MIMEType Size Downloads

Title Paternal under-nutrition programs metabolic syndrome in offspring which can be reversed by antioxidant/vitamin food fortification in fathers
Author(s) McPherson, Nicole O.
Fullston, Tod
Kang, Wan Xian
Sandeman, Lauren Y.
Corbett, Mark A.
Owens, Julie A.ORCID iD for Owens, Julie A. orcid.org/0000-0002-7498-1353
Lane, Michelle
Journal name Scientific reports
Volume number 6
Article ID 27010
Start page 1
End page 14
Total pages 14
Publisher Springer Nature
Place of publication London, Eng.
Publication date 2016-06-03
ISSN 2045-2322
Keyword(s) Adiposity
Animals
Antioxidants
Body Composition
Embryonic Development
Female
Food, Fortified
Founder Effect
Infertility, Male
Insulin
Leptin
Lipids
Male
Malnutrition
Metabolic Syndrome
Mice, Inbred C57BL
Paternal Inheritance
Reactive Oxygen Species
Sperm Count
Sperm Motility
Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
HIGH-FAT DIET
BODY-MASS INDEX
CHILD UNDERNUTRITION
CALORIC RESTRICTION
HUMAN SPERMATOZOA
OXIDATIVE STRESS
GENE-EXPRESSION
SPERM FUNCTION
OBESITY
MICE
Summary There is an ever increasing body of evidence that demonstrates that paternal over-nutrition prior to conception programs impaired metabolic health in offspring. Here we examined whether paternal under-nutrition can also program impaired health in offspring and if any detrimental health outcomes in offspring could be prevented by micronutrient supplementation (vitamins and antioxidants). We discovered that restricting the food intake of male rodents reduced their body weight, fertility, increased sperm oxidative DNA lesions and reduced global sperm methylation. Under-nourished males then sired offspring with reduced postnatal weight and growth but somewhat paradoxically increased adiposity and dyslipidaemia, despite being fed standard chow. Paternal vitamin/antioxidant food fortification during under-nutrition not only normalised founder oxidative sperm DNA lesions but also prevented early growth restriction, fat accumulation and dyslipidaemia in offspring. This demonstrates that paternal under-nutrition reduces postnatal growth but increases the risk of obesity and metabolic disease in the next generation and that micronutrient supplementation during this period of under-nutrition is capable of restoring offspring metabolic health.
Language eng
DOI 10.1038/srep27010
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2016, The Authors
Persistent URL http://hdl.handle.net/10536/DRO/DU:30116334

Document type: Journal Article
Collections: Office of the Deputy Vice-Chancellor Research
Open Access Checking
Connect to link resolver
 
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 10 times in TR Web of Science
Scopus Citation Count Cited 10 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 39 Abstract Views, 1 File Downloads  -  Detailed Statistics
Created: Wed, 16 Jan 2019, 14:32:32 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.