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The effect of an antenatal lifestyle intervention in overweight and obese women on circulating cardiometabolic and inflammatory biomarkers: secondary analyses from the LIMIT randomised trial

Moran, Lisa J, Fraser, Louise M, Sundernathan, Tulika, Deussen, Andrea R, Louise, Jennie, Yelland, Lisa N, Grivell, Rosalie M, Macpherson, Anne, Gillman, Matthew W, Robinson, Jeffrey S, Owens, Julie A and Dodd, Jodie M 2017, The effect of an antenatal lifestyle intervention in overweight and obese women on circulating cardiometabolic and inflammatory biomarkers: secondary analyses from the LIMIT randomised trial, BMC medicine, vol. 15, pp. 1-12, doi: 10.1186/s12916-017-0790-z.

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Title The effect of an antenatal lifestyle intervention in overweight and obese women on circulating cardiometabolic and inflammatory biomarkers: secondary analyses from the LIMIT randomised trial
Author(s) Moran, Lisa J
Fraser, Louise M
Sundernathan, Tulika
Deussen, Andrea R
Louise, Jennie
Yelland, Lisa N
Grivell, Rosalie M
Macpherson, Anne
Gillman, Matthew W
Robinson, Jeffrey S
Owens, Julie AORCID iD for Owens, Julie A orcid.org/0000-0002-7498-1353
Dodd, Jodie M
Journal name BMC medicine
Volume number 15
Article ID 32
Start page 1
End page 12
Total pages 12
Publisher Bio Med Central
Place of publication London, Eng.
Publication date 2017-02-14
ISSN 1741-7015
Keyword(s) Cardiometabolic markers
Dietary and lifestyle intervention
Inflammatory markers
Overweight and obesity
Pregnancy
Randomised trial
Adult
Biomarkers
Cardiovascular Diseases
Female
Humans
Life Style
Obesity
Overweight
Pregnancy Complications
Prenatal Care
Science & Technology
Life Sciences & Biomedicine
Medicine, General & Internal
General & Internal Medicine
GESTATIONAL DIABETES-MELLITUS
C-REACTIVE PROTEIN
BODY-MASS INDEX
NECROSIS-FACTOR-ALPHA
WEIGHT-GAIN
PREGNANT-WOMEN
INSULIN-RESISTANCE
HEALTH OUTCOMES
CARDIOVASCULAR-DISEASE
METABOLIC SYNDROME
Summary BACKGROUND: Maternal overweight and obesity during pregnancy is associated with insulin resistance, hyperglycaemia, hyperlipidaemia and a low-grade state of chronic inflammation. The aim of this pre-specified analysis of secondary outcome measures was to evaluate the effect of providing antenatal dietary and lifestyle advice on cardiometabolic and inflammatory biomarkers. METHODS: We conducted a multicentre trial in which pregnant women who were overweight or obese were randomised to receive either Lifestyle Advice or Standard Care. We report a range of pre-specified secondary maternal and newborn cardiometabolic and inflammatory biomarker outcomes. Maternal whole venous blood was collected at trial entry (mean 14 weeks gestation; non-fasting), at 28 weeks gestation (fasting), and at 36 weeks gestation (non-fasting). Cord blood was collected after birth and prior to the delivery of the placenta. A range of cardiometabolic and inflammatory markers were analysed (total cholesterol, triglycerides, non-esterified fatty acids, high-density lipoprotein cholesterol, insulin, glucose, leptin, adiponectin, C-reactive protein, granulocyte macrophage-colony stimulating factor, interferon gamma, TNF-α, and interleukins 1β, 2, 4, 5, 6, 8, and 10). Participants were analysed in the groups to which they were randomised, and were included in the analyses if they had a measure at any time point. RESULTS: One or more biological specimens were available from 1951 women (989 Lifestyle Advice and 962 Standard Care), with cord blood from 1174 infants (596 Lifestyle Advice and 578 Standard Care). There were no statistically significant differences in mean cardiometabolic and inflammatory marker concentrations across pregnancy and in infant cord blood between treatment groups. Estimated treatment group differences were close to zero, with 95% confidence intervals spanning a range of differences that were short of clinical relevance. There was no evidence to suggest that the intervention effect was modified by maternal BMI category. CONCLUSIONS: Despite our findings, it will be worth considering potential relationships between cardiometabolic and inflammatory markers and clinical outcomes, including longer-term infant health and adiposity. TRIAL REGISTRATION: Australian and New Zealand Clinical Trials Registry ( ACTRN12607000161426 ; Date Registered 09/03/2007).
Language eng
DOI 10.1186/s12916-017-0790-z
Indigenous content off
Field of Research 11 Medical And Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2017, The Author(s)
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30116337

Document type: Journal Article
Collections: Office of the Deputy Vice-Chancellor (Research)
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.