Small size at birth predicts decreased cardiomyocyte number in the adult ovine heart

Vranas, S., Heinemann, G. K., Liu, H., De Blasio, M. J., Owens, J. A., Gatford, K. L. and Black, M. J. 2017, Small size at birth predicts decreased cardiomyocyte number in the adult ovine heart, Journal of developmental origins of health and disease, vol. 8, no. 5, pp. 618-625, doi: 10.1017/S2040174417000381.

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Title Small size at birth predicts decreased cardiomyocyte number in the adult ovine heart
Author(s) Vranas, S.
Heinemann, G. K.
Liu, H.
De Blasio, M. J.
Owens, J. A.ORCID iD for Owens, J. A. orcid.org/0000-0002-7498-1353
Gatford, K. L.
Black, M. J.
Journal name Journal of developmental origins of health and disease
Volume number 8
Issue number 5
Start page 618
End page 625
Total pages 8
Publisher Cambridge University Press
Place of publication Cambridge, Eng.
Publication date 2017-10
ISSN 2040-1752
Keyword(s) IUGR
birth weight
cardiomyocyte
heart
sheep
Age Factors
Animals
Cell Count
Cell Size
Female
Forecasting
Humans
Male
Myocardium
Myocytes, Cardiac
Pregnancy
Science & Technology
Life Sciences & Biomedicine
Public, Environmental & Occupational Health
INTRAUTERINE GROWTH RESTRICTION
ALTERS POSTNATAL-GROWTH
PLACENTAL RESTRICTION
FETAL SHEEP
CARDIOVASCULAR-DISEASE
CARDIAC MYOCYTES
YOUNG LAMB
WEIGHT
RAT
PROLIFERATION
Summary Low birth weight is associated with increased risk of cardiovascular disease in adulthood. Intrauterine growth restriction (IUGR) hearts have fewer CMs in early postnatal life, which may impair postnatal cardiovascular function and hence, explain increased disease risk, but whether the cardiomyocyte deficit persists to adult life is unknown. We therefore studied the effects of experimentally induced placental restriction (PR) on cardiac outcomes in young adult sheep. Heart size, cardiomyocyte number, nuclearity and size were measured in control (n=5) and PR (n=5) male sheep at 1 year of age. PR lambs were 36% lighter at birth (P=0.007), had 38% faster neonatal relative growth rates (P=0.001) and had 21% lighter heart weights relative to body weight as adults (P=0.024) than control lambs. Cardiomyocyte number, nuclearity and size in the left ventricle did not differ between control and PR adults; hearts of both groups contained cardiomyocytes (CM) with between one and four nuclei. Overall, cardiomyocyte number in the adult left ventricle correlated positively with birth weight but not with adult weight. This study is the first to demonstrate that intrauterine growth directly influences the complement of CM in the adult heart. Cardiomyocyte size was not correlated with cardiomyocyte number or birth weight. Our results suggest that body weight at birth affects lifelong cardiac functional reserve. We hypothesise that decreased cardiomyocyte number of low birth weight individuals may impair their capacity to adapt to additional challenges such as obesity and ageing.
Language eng
DOI 10.1017/S2040174417000381
Field of Research 11 Medical And Health Sciences
HERDC Research category CN.1 Other journal article
Copyright notice ©2017, Cambridge University Press and the International Society for Developmental Origins of Health and Disease
Persistent URL http://hdl.handle.net/10536/DRO/DU:30116636

Document type: Journal Article
Collection: Office of the Deputy Vice-Chancellor (Research)
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