Maternal insulin-like growth factors-I and -II act via different pathways to promote fetal growth

Sferruzzi-Perri, Amanda N., Owens, Julie A., Pringle, Kirsty G., Robinson, Jeffrey S. and Roberts, Claire T. 2006, Maternal insulin-like growth factors-I and -II act via different pathways to promote fetal growth, Endocrinology, vol. 147, no. 7, pp. 3344-3355, doi: 10.1210/en.2005-1328.

Attached Files
Name Description MIMEType Size Downloads

Title Maternal insulin-like growth factors-I and -II act via different pathways to promote fetal growth
Author(s) Sferruzzi-Perri, Amanda N.
Owens, Julie A.ORCID iD for Owens, Julie A.
Pringle, Kirsty G.
Robinson, Jeffrey S.
Roberts, Claire T.
Journal name Endocrinology
Volume number 147
Issue number 7
Start page 3344
End page 3355
Total pages 12
Publisher Oxford University Press
Place of publication Oxford, Eng.
Publication date 2006-07
ISSN 0013-7227
Keyword(s) Animals
Fetal Development
Guinea Pigs
Insulin-Like Growth Factor Binding Proteins
Insulin-Like Growth Factor I
Insulin-Like Growth Factor II
Maternal-Fetal Exchange
Pregnancy Outcome
Pregnancy, Animal
Science & Technology
Life Sciences & Biomedicine
Endocrinology & Metabolism
Summary The placenta transports substrates and wastes between the maternal and fetal circulations. In mice, placental IGF-II is essential for normal placental development and function but, in other mammalian species, maternal circulating IGF-II is substantial and may contribute. Maternal circulating IGFs increase in early pregnancy, and early treatment of guinea pigs with either IGF-I or IGF-II increases placental and fetal weights by mid-gestation. We now show that these effects persist to enhance placental development and fetal growth and survival near term. Pregnant guinea pigs were infused with IGF-I, IGF-II (both 1 mg/kg.d), or vehicle sc from d 20-38 of pregnancy and killed on d 62 (term = 69 d). IGF-II, but not IGF-I, increased the mid-sagittal area and volume of placenta devoted to exchange by approximately 30%, the total volume of trophoblast and maternal blood spaces within the placental exchange region (+29% and +46%, respectively), and the total surface area of placenta for exchange by 39%. Both IGFs reduced resorptions, and IGF-II increased the number of viable fetuses by 26%. Both IGFs increased fetal weight by 11-17% and fetal circulating amino acid concentrations. IGF-I, but not IGF-II, reduced maternal adipose depot weights by approximately 30%. In conclusion, increased maternal IGF-II abundance in early pregnancy promotes fetal growth and viability near term by increasing placental structural and functional capacity, whereas IGF-I appears to divert nutrients from the mother to the conceptus. This suggests major and complementary roles in placental and fetal growth for increased circulating IGFs in early to mid-pregnancy.
Language eng
DOI 10.1210/en.2005-1328
Field of Research 07 Agricultural And Veterinary Sciences
11 Medical And Health Sciences
06 Biological Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2006, The Endocrine Society
Persistent URL

Document type: Journal Article
Collection: Office of the Deputy Vice-Chancellor (Research)
Connect to link resolver
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 63 times in TR Web of Science
Scopus Citation Count Cited 68 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 93 Abstract Views, 0 File Downloads  -  Detailed Statistics
Created: Wed, 16 Jan 2019, 14:14:13 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact