Maternal insulin-like growth factors-I and -II act via different pathways to promote fetal growth

Sferruzzi-Perri, Amanda N., Owens, Julie A., Pringle, Kirsty G., Robinson, Jeffrey S. and Roberts, Claire T. 2006, Maternal insulin-like growth factors-I and -II act via different pathways to promote fetal growth, Endocrinology, vol. 147, no. 7, pp. 3344-3355, doi: 10.1210/en.2005-1328.

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Title Maternal insulin-like growth factors-I and -II act via different pathways to promote fetal growth
Author(s) Sferruzzi-Perri, Amanda N.
Owens, Julie A.ORCID iD for Owens, Julie A. orcid.org/0000-0002-7498-1353
Pringle, Kirsty G.
Robinson, Jeffrey S.
Roberts, Claire T.
Journal name Endocrinology
Volume number 147
Issue number 7
Start page 3344
End page 3355
Total pages 12
Publisher Oxford University Press
Place of publication Oxford, Eng.
Publication date 2006-07
ISSN 0013-7227
Keyword(s) Animals
Female
Fetal Development
Guinea Pigs
Insulin-Like Growth Factor Binding Proteins
Insulin-Like Growth Factor I
Insulin-Like Growth Factor II
Male
Maternal-Fetal Exchange
Mice
Mothers
Placenta
Pregnancy
Pregnancy Outcome
Pregnancy, Animal
Trophoblasts
Science & Technology
Life Sciences & Biomedicine
Endocrinology & Metabolism
FOR-GESTATIONAL-AGE
AMINO-ACID-UPTAKE
ADULT GUINEA-PIG
IGF-II
FOOD RESTRICTION
HUMAN PLACENTA
FEED RESTRICTION
BINDING-PROTEINS
PHYSIOLOGICAL TRANSFORMATION
EXTRAVILLOUS TROPHOBLAST
Summary The placenta transports substrates and wastes between the maternal and fetal circulations. In mice, placental IGF-II is essential for normal placental development and function but, in other mammalian species, maternal circulating IGF-II is substantial and may contribute. Maternal circulating IGFs increase in early pregnancy, and early treatment of guinea pigs with either IGF-I or IGF-II increases placental and fetal weights by mid-gestation. We now show that these effects persist to enhance placental development and fetal growth and survival near term. Pregnant guinea pigs were infused with IGF-I, IGF-II (both 1 mg/kg.d), or vehicle sc from d 20-38 of pregnancy and killed on d 62 (term = 69 d). IGF-II, but not IGF-I, increased the mid-sagittal area and volume of placenta devoted to exchange by approximately 30%, the total volume of trophoblast and maternal blood spaces within the placental exchange region (+29% and +46%, respectively), and the total surface area of placenta for exchange by 39%. Both IGFs reduced resorptions, and IGF-II increased the number of viable fetuses by 26%. Both IGFs increased fetal weight by 11-17% and fetal circulating amino acid concentrations. IGF-I, but not IGF-II, reduced maternal adipose depot weights by approximately 30%. In conclusion, increased maternal IGF-II abundance in early pregnancy promotes fetal growth and viability near term by increasing placental structural and functional capacity, whereas IGF-I appears to divert nutrients from the mother to the conceptus. This suggests major and complementary roles in placental and fetal growth for increased circulating IGFs in early to mid-pregnancy.
Language eng
DOI 10.1210/en.2005-1328
Field of Research 07 Agricultural And Veterinary Sciences
11 Medical And Health Sciences
06 Biological Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2006, The Endocrine Society
Persistent URL http://hdl.handle.net/10536/DRO/DU:30116754

Document type: Journal Article
Collection: Office of the Deputy Vice-Chancellor (Research)
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