Improved lactational nutrition and postnatal growth ameliorates impairment of glucose tolerance by uteroplacental insufficiency in male rat offspring

Siebel, Andrew L., Mibus, Amy, De Blasio, Miles J., Westcott, Kerryn T., Morris, Margaret J., Prior, Larissa, Owens, Julie A. and Wlodek, Mary E. 2008, Improved lactational nutrition and postnatal growth ameliorates impairment of glucose tolerance by uteroplacental insufficiency in male rat offspring, Endocrinology, vol. 149, no. 6, pp. 3067-3076, doi: 10.1210/en.2008-0128.

Attached Files
Name Description MIMEType Size Downloads

Title Improved lactational nutrition and postnatal growth ameliorates impairment of glucose tolerance by uteroplacental insufficiency in male rat offspring
Author(s) Siebel, Andrew L.
Mibus, Amy
De Blasio, Miles J.
Westcott, Kerryn T.
Morris, Margaret J.
Prior, Larissa
Owens, Julie A.ORCID iD for Owens, Julie A. orcid.org/0000-0002-7498-1353
Wlodek, Mary E.
Journal name Endocrinology
Volume number 149
Issue number 6
Start page 3067
End page 3076
Total pages 10
Publisher Oxford University Press
Place of publication Oxford, Eng.
Publication date 2008-06
ISSN 0013-7227
Keyword(s) Animals
Energy Intake
Female
Glucose Intolerance
Growth
Lactation
Male
Placental Circulation
Placental Insufficiency
Pregnancy
Rats
Sex Characteristics
Uterus
Science & Technology
Life Sciences & Biomedicine
Endocrinology & Metabolism
HYPOTHALAMIC NEUROPEPTIDE-Y
ADULT LIFE
SKELETAL-MUSCLE
BLOOD-PRESSURE
INSULIN ACTION
FETAL-GROWTH
CARDIOVASCULAR-DISEASE
PLACENTAL RESTRICTION
METABOLIC SYNDROME
RISK-FACTORS
Summary Intrauterine growth restriction and accelerated postnatal growth predict increased risk of diabetes. Uteroplacental insufficiency in the rat restricts fetal growth but also impairs mammary development and postnatal growth. We used cross fostering to compare the influence of prenatal and postnatal nutritional restraint on adult glucose tolerance, insulin secretion, insulin sensitivity, and hypothalamic neuropeptide Y content in Wistar Kyoto rats at 6 months of age. Bilateral uterine vessel ligation (restricted) to induce uteroplacental insufficiency or sham surgery (control) was performed on d-18 gestation. Control, restricted, and reduced (reducing litter size of controls to match restricted) pups were cross fostered onto a control or restricted mother 1 d after birth. Restricted pups were born small compared with controls. Restricted males, but not females, remained lighter up to 6 months, regardless of postnatal environment. By 10 wk, restricted-on-restricted males ate more than controls. At 6 months restricted-on-restricted males had increased hypothalamic neuropeptide Y content compared with other groups, and together with reduced-on-restricted males had increased retroperitoneal fat weight (percent body weight) compared with control-on-controls. Restricted-on-restricted males had impaired glucose tolerance, reduced first-phase insulin secretion, but unaltered insulin sensitivity, compared with control-on-controls. In males, being born small and exposed to an impaired lactational environment adversely affects adult glucose tolerance and first-phase insulin secretion, but improving lactation partially ameliorates this condition. This study identifies early life as a target for intervention to prevent later diabetes after prenatal restraint.
Language eng
DOI 10.1210/en.2008-0128
Field of Research 07 Agricultural And Veterinary Sciences
11 Medical And Health Sciences
06 Biological Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2008, The Endocrine Society
Persistent URL http://hdl.handle.net/10536/DRO/DU:30116770

Document type: Journal Article
Collection: Office of the Deputy Vice-Chancellor Research
Connect to link resolver
 
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 58 times in TR Web of Science
Scopus Citation Count Cited 57 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 40 Abstract Views, 0 File Downloads  -  Detailed Statistics
Created: Wed, 16 Jan 2019, 14:18:50 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.