Early pregnancy maternal endocrine insulin-like growth factor I programs the placenta for increased functional capacity throughout gestation

Sferruzzi-Perri, Amanda N., Owens, Julie A., Standen, Prue, Taylor, Robyn L., Robinson, Jeffrey S. and Roberts, Claire T. 2007, Early pregnancy maternal endocrine insulin-like growth factor I programs the placenta for increased functional capacity throughout gestation, Endocrinology, vol. 148, no. 9, pp. 4362-4370, doi: 10.1210/en.2007-0411.

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Title Early pregnancy maternal endocrine insulin-like growth factor I programs the placenta for increased functional capacity throughout gestation
Author(s) Sferruzzi-Perri, Amanda N.
Owens, Julie A.ORCID iD for Owens, Julie A. orcid.org/0000-0002-7498-1353
Standen, Prue
Taylor, Robyn L.
Robinson, Jeffrey S.
Roberts, Claire T.
Journal name Endocrinology
Volume number 148
Issue number 9
Start page 4362
End page 4370
Total pages 9
Publisher Oxford University Press
Place of publication Oxford, Eng.
Publication date 2007-09-01
ISSN 0013-7227
Keyword(s) Aminoisobutyric Acids
Animals
Biological Transport
Birth Weight
DNA Primers
Female
Gene Expression Regulation
Guinea Pigs
Insulin-Like Growth Factor I
Insulin-Like Growth Factor II
Methylglucosides
Organ Size
Placenta
Pregnancy
RNA, Messenger
Science & Technology
Life Sciences & Biomedicine
Endocrinology & Metabolism
AMINO-ACID-TRANSPORT
FACILITATIVE GLUCOSE-TRANSPORTER
HUMAN HEPATOCELLULAR-CARCINOMA
GUINEA-PIG PLACENTA
FETAL-GROWTH
IGF-I
QUANTITATIVE METHOD
TROPHOBLAST CELLS
ALANINE TRANSPORT
BINDING-PROTEINS
Summary In early pregnancy, the concentrations of IGFs increase in maternal blood. Treatment of pregnant guinea pigs with IGFs in early to midpregnancy enhances placental glucose transport and fetal growth and viability near term. In the current study, we determined whether exogenous IGFs altered placental gene expression, transport, and nutrient partitioning during treatment, which may then persist. Guinea pigs were infused with IGF-I, IGF-II (both 1 mg/kg x d) or vehicle sc from d 20-35 of pregnancy and killed on d 35 (term is 70 d) after administration of [(3)H]methyl-D-glucose (MG) and [(14)C]amino-isobutyric acid (AIB). IGF-I increased placental and fetal weights (+15 and +17%, respectively) and MG and AIB uptake by the placenta (+42 and +68%, respectively) and fetus (+59 and +90%, respectively). IGF-I increased placental mRNA expression of the amino acid transporter gene Slc38a2 (+780%) and reduced that of Igf2 (-51%), without altering the glucose transporter Slc2a1 or Vegf and Igf1 genes. There were modest effects of IGF-I treatment on MG and AIB uptake by individual maternal tissues and no effect on plasma glucose, total amino acids, free fatty acids, triglycerides, and cholesterol concentrations. IGF-II treatment of the mother did not alter any maternal, fetal or placental parameter. In conclusion, exogenous IGF-I, but not IGF-II, in early pregnancy increases placental transport of MG and AIB, enhancing midgestational fetal nutrient uptake and growth. This suggests that early pregnancy rises in maternal circulating IGF-I play a major role in regulating placental growth and functional development and thus fetal growth throughout gestation.
Language eng
DOI 10.1210/en.2007-0411
Field of Research 07 Agricultural And Veterinary Sciences
11 Medical And Health Sciences
06 Biological Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2007, The Endocrine Society
Persistent URL http://hdl.handle.net/10536/DRO/DU:30116774

Document type: Journal Article
Collection: Office of the Deputy Vice-Chancellor Research
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