Dietary protein during gestation affects maternal insulin-like growth factor, insulin-like growth factor binding protein, leptin concentrations, and fetal growth in heifers

Sullivan, T. M., Micke, G. C., Perkins, N., Martin, G. B., Wallace, C. R., Gatford, K. L., Owens, J. A. and Perry, V. E. A. 2009, Dietary protein during gestation affects maternal insulin-like growth factor, insulin-like growth factor binding protein, leptin concentrations, and fetal growth in heifers, Journal of animal science, vol. 87, no. 10, pp. 3304-3316, doi: 10.2527/jas.2008-1753.

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Title Dietary protein during gestation affects maternal insulin-like growth factor, insulin-like growth factor binding protein, leptin concentrations, and fetal growth in heifers
Author(s) Sullivan, T. M.
Micke, G. C.
Perkins, N.
Martin, G. B.
Wallace, C. R.
Gatford, K. L.
Owens, J. A.ORCID iD for Owens, J. A. orcid.org/0000-0002-7498-1353
Perry, V. E. A.
Journal name Journal of animal science
Volume number 87
Issue number 10
Start page 3304
End page 3316
Total pages 13
Publisher Oxford University Press
Place of publication Oxford, Eng.
Publication date 2009-10-01
ISSN 1525-3163
Keyword(s) Age Factors
Animals
Animals, Newborn
Birth Weight
Cattle
Crown-Rump Length
Dietary Proteins
Female
Genotype
Insulin-Like Growth Factor Binding Proteins
Insulin-Like Growth Factor I
Insulin-Like Growth Factor II
Leptin
Placental Lactogen
Pregnancy
Queensland
Science & Technology
Life Sciences & Biomedicine
Agriculture, Dairy & Animal Science
Agriculture
crude protein
fetal growth
gestation
insulin-like growth factor
MESSENGER-RNA LEVELS
I IGF-I
CIRCULATING INSULIN
PLASMA-CONCENTRATIONS
PLACENTAL-LACTOGEN
BODY CONDITION
BEEF-CATTLE
DAIRY-COWS
NUTRITIONAL REGULATION
SERUM CONCENTRATIONS
Summary The influence of supplemental protein during gestation on maternal hormones and fetal growth was determined in composite beef heifers. At AI, 118 heifers were stratified by BW within each composite genotype (BeefX = 1/2 Senepol, 1/4 Brahman, 1/8 Charolais, 1/8 Red Angus and CBX = 1/2 Senepol, 1/4 Brahman, 1/4 Charolais) into 4 treatment groups: high high (HH = 1.4 kg CP/d for first and second trimesters of gestation), high low (HL = 1.4 kg of CP/d for first trimester and 0.4 kg of CP/d for second trimester), low high (lowH = 0.4 kg CP/d for first trimester and 1.4 kg of CP/d and for second trimester), or low low (LL = 0.4 kg CP/d for first and second trimesters). Maternal plasma IGF-I and -II, total IGFBP, and leptin concentrations were determined at 14 d before AI and at d 28, 82, 179, and 271 post-AI (mean gestation length 286 d), and leptin concentrations were also determined at calving. Increased dietary protein increased maternal plasma IGF-I (P < 0.001 on d 28, 82, and 179), IGF-II (P = 0.01 on d 82; P = 0.04 on d 271), and total IGFBP (P = 0.002 on d 82; P = 0.005 on d 179; P = 0.03 on d 271). Maternal plasma IGF-I at d 271 was negatively associated with calf crown-rump length at birth (P = 0.003). BeefX had greater birth weight calves (P = 0.01), greater IGF-II (P < 0.001), increased ratios of IGF-I:total IGFBP (P = 0.008) and IGF-II:total IGFBP (P < 0.001), and reduced total IGFBP compared with CBX (P = 0.02). Increased dietary protein during second trimester increased maternal plasma leptin at calving (P = 0.005). Maternal plasma leptin near term was positively associated with heifer BCS (P = 0.02) and with calf birth weight (P = 0.04), and at calving was positively associated with heifer age at AI (P = 0.02). These findings suggest that maternal dietary protein, age, and genotype influence plasma concentrations of metabolic hormones and fetal growth in Bos indicus-influenced heifers.
Language eng
DOI 10.2527/jas.2008-1753
Field of Research 07 Agricultural And Veterinary Sciences
06 Biological Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2009, American Society of Animal Science
Persistent URL http://hdl.handle.net/10536/DRO/DU:30116782

Document type: Journal Article
Collection: Office of the Deputy Vice-Chancellor (Research)
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