Paternal obesity initiates metabolic disturbances in two generations of mice with incomplete penetrance to the F₂ generation and alters the transcriptional profile of testis and sperm microRNA content

Fullston, Tod, Ohlsson Teague, E. Maria C., Palmer, Nicole O., DeBlasio, Miles J., Mitchell, Megan, Corbett, Mark, Print, Cristin G., Owens, Julie A. and Lane, Michelle 2013, Paternal obesity initiates metabolic disturbances in two generations of mice with incomplete penetrance to the F₂ generation and alters the transcriptional profile of testis and sperm microRNA content, FASEB journal, vol. 27, no. 10, pp. 4226-4243, doi: 10.1096/fj.12-224048.


Title Paternal obesity initiates metabolic disturbances in two generations of mice with incomplete penetrance to the F₂ generation and alters the transcriptional profile of testis and sperm microRNA content
Author(s) Fullston, Tod
Ohlsson Teague, E. Maria C.
Palmer, Nicole O.
DeBlasio, Miles J.
Mitchell, Megan
Corbett, Mark
Print, Cristin G.
Owens, Julie A.ORCID iD for Owens, Julie A. orcid.org/0000-0002-7498-1353
Lane, Michelle
Journal name FASEB journal
Volume number 27
Issue number 10
Start page 4226
End page 4243
Total pages 18
Publisher Federation of American Societies for Experimental Biology
Place of publication Bethesda, Md.
Publication date 2013-10
ISSN 1530-6860
Keyword(s) DNA damage
ROS
epigenetic alteration
methylation
nongenetic transmission
Animals
Energy Metabolism
Female
Gene Expression Regulation
Glucose Tolerance Test
Insulin Resistance
Male
Mice
Mice, Inbred C57BL
MicroRNAs
Obesity
Reactive Oxygen Species
Sex Factors
Spermatozoa
Testis
Transcriptome
Science & Technology
Life Sciences & Biomedicine
Biochemistry & Molecular Biology
Biology
Cell Biology
Life Sciences & Biomedicine - Other Topics
BODY-MASS INDEX
DIET-INDUCED OBESITY
HIGH-FAT DIET
REAL-TIME PCR
SEMEN QUALITY
REPRODUCTIVE HORMONES
EMBRYO DEVELOPMENT
HUMAN SPERMATOZOA
MIRNA EXPRESSION
GENE-EXPRESSION
Language eng
DOI 10.1096/fj.12-224048
Field of Research 0601 Biochemistry And Cell Biology
0606 Physiology
1116 Medical Physiology
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2013, Federation of American Societies for Experimental Biology
Persistent URL http://hdl.handle.net/10536/DRO/DU:30116799

Document type: Journal Article
Collection: Office of the Deputy Vice-Chancellor (Research)
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