Diet-induced paternal obesity in the absence of diabetes diminishes the reproductive health of two subsequent generations of mice

Fullston, T., Palmer, N.O., Owens, J.A., Mitchell, M., Bakos, H.W. and Lane, M. 2012, Diet-induced paternal obesity in the absence of diabetes diminishes the reproductive health of two subsequent generations of mice, Human reproduction, vol. 27, no. 5, pp. 1391-1400, doi: 10.1093/humrep/des030.

Attached Files
Name Description MIMEType Size Downloads

Title Diet-induced paternal obesity in the absence of diabetes diminishes the reproductive health of two subsequent generations of mice
Author(s) Fullston, T.
Palmer, N.O.
Owens, J.A.ORCID iD for Owens, J.A. orcid.org/0000-0002-7498-1353
Mitchell, M.
Bakos, H.W.
Lane, M.
Journal name Human reproduction
Volume number 27
Issue number 5
Start page 1391
End page 1400
Total pages 10
Publisher Oxford University Press
Place of publication Oxford, Eng.
Publication date 2012-05
ISSN 1460-2350
Keyword(s) Animals
Diet, High-Fat
Female
Infertility
Male
Mice
Mice, Inbred C57BL
Obesity
Preconception Injuries
Science & Technology
Life Sciences & Biomedicine
Obstetrics & Gynecology
Reproductive Biology
paternal obesity
fertilization
DNA damage
sperm quality
oocyte quality
BODY-MASS INDEX
HIGH-FAT DIET
SPERM FUNCTION
SEMEN QUALITY
MOUSE OOCYTES
IMPACT
OVERWEIGHT
MATURATION
Summary BACKGROUND: Obesity and related conditions, notably subfertility, are increasingly prevalent. Paternal influences are known to influence offspring health outcome, but the impact of paternal obesity and subfertility on the reproductive health of subsequent generations has been overlooked. METHODS: A high-fat diet (HFD) was used to induce obesity but not diabetes in male C57Bl6 mice, which were subsequently mated to normal-weight females. First-generation offspring were raised on a control diet and their gametes were investigated for signs of subfertility. Second-generation offspring were generated from both first generation sexes and their gametes were similarly assessed. RESULTS: We demonstrate a HFD-induced paternal initiation of subfertility in both male and female offspring of two generations of mice. Furthermore, we have shown that diminished reproductive and gamete functions are transmitted through the first generation paternal line to both sexes of the second generation and via the first generation maternal line to second-generation males. Our previous findings that founder male obesity alters the epigenome of sperm, could provide a basis for the developmental programming of subfertility in subsequent generations. CONCLUSIONS: This is the first observation of paternal transmission of diminished reproductive health to future generations and could have significant implications for the transgenerational amplification of subfertility observed worldwide in humans.
Language eng
DOI 10.1093/humrep/des030
Field of Research 16 Studies In Human Society
11 Medical And Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2012, The Author
Persistent URL http://hdl.handle.net/10536/DRO/DU:30116806

Document type: Journal Article
Collection: Office of the Deputy Vice-Chancellor (Research)
Connect to link resolver
 
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 89 times in TR Web of Science
Scopus Citation Count Cited 97 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 98 Abstract Views, 0 File Downloads  -  Detailed Statistics
Created: Wed, 16 Jan 2019, 14:27:09 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.