Potential role of folate in pre-eclampsia

Singh, Mansi Dass, Thomas, Philip, Owens, Julie, Hague, William and Fenech, Michael 2015, Potential role of folate in pre-eclampsia, Nutrition reviews, vol. 73, no. 10, pp. 694-722, doi: 10.1093/nutrit/nuv028.

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Title Potential role of folate in pre-eclampsia
Author(s) Singh, Mansi Dass
Thomas, Philip
Owens, JulieORCID iD for Owens, Julie orcid.org/0000-0002-7498-1353
Hague, William
Fenech, Michael
Journal name Nutrition reviews
Volume number 73
Issue number 10
Start page 694
End page 722
Total pages 29
Publisher Oxford University Press
Place of publication Oxford, Eng.
Publication date 2015-10
ISSN 1753-4887
Keyword(s) DNA methylation
folate
genome instability
one-carbon metabolism
polymorphism
pre-eclampsia
Dietary Supplements
Female
Folic Acid
Folic Acid Deficiency
Genomic Instability
Humans
Methionine
Oxidative Stress
Polymorphism, Genetic
Pregnancy
Vitamins
Science & Technology
Life Sciences & Biomedicine
Nutrition & Dietetics
METHYLENETETRAHYDROFOLATE-REDUCTASE GENE
FOLIC-ACID SUPPLEMENTATION
INTRAUTERINE GROWTH RESTRICTION
PLASMA TOTAL HOMOCYSTEINE
GLOBAL DNA METHYLATION
EARLY-ONSET PREECLAMPSIA
PERICONCEPTIONAL MULTIVITAMIN USE
PREGNANCY-INDUCED HYPERTENSION
IMPROVES ENDOTHELIAL FUNCTION
PERIPHERAL-BLOOD LYMPHOCYTES
Summary Dietary deficiencies of folate and other B vitamin cofactors involved in one-carbon metabolism, together with genetic polymorphisms in key folate-methionine metabolic pathway enzymes, are associated with increases in circulating plasma homocysteine, reduction in DNA methylation patterns, and genome instability events. All of these biomarkers have also been associated with pre-eclampsia. The aim of this review was to explore the literature and identify potential knowledge gaps in relation to the role of folate at the genomic level in either the etiology or the prevention of pre-eclampsia. A systematic search strategy was designed to identify citations in electronic databases for the following terms: folic acid supplementation AND pre-eclampsia, folic acid supplementation AND genome stability, folate AND genome stability AND pre-eclampsia, folic acid supplementation AND DNA methylation, and folate AND DNA methylation AND pre-eclampsia. Forty-three articles were selected according to predefined selection criteria. The studies included in the present review were not homogeneous, which made pooled analysis of the data very difficult. The present review highlights associations between folate deficiency and certain biomarkers observed in various tissues of women at risk of pre-eclampsia. Further investigation is required to understand the role of folate in either the etiology or the prevention of pre-eclampsia.
Language eng
DOI 10.1093/nutrit/nuv028
Field of Research 11 Medical And Health Sciences
17 Psychology And Cognitive Sciences
HERDC Research category CN.1 Other journal article
Copyright notice ©2015, The Author(s)
Persistent URL http://hdl.handle.net/10536/DRO/DU:30116815

Document type: Journal Article
Collection: Office of the Deputy Vice-Chancellor (Research)
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