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An exercise-only intervention in obese fathers restores glucose and insulin regulation in conjunction with the rescue of pancreatic islet cell morphology and MicroRNA expression in male offspring

McPherson, Nicole O., Lane, Michelle, Sandeman, Lauren, Owens, Julie A. and Fullston, Tod 2017, An exercise-only intervention in obese fathers restores glucose and insulin regulation in conjunction with the rescue of pancreatic islet cell morphology and MicroRNA expression in male offspring, Nutrients, vol. 9, no. 2, pp. 1-17, doi: 10.3390/nu9020122.

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Title An exercise-only intervention in obese fathers restores glucose and insulin regulation in conjunction with the rescue of pancreatic islet cell morphology and MicroRNA expression in male offspring
Author(s) McPherson, Nicole O.
Lane, Michelle
Sandeman, Lauren
Owens, Julie A.ORCID iD for Owens, Julie A. orcid.org/0000-0002-7498-1353
Fullston, Tod
Journal name Nutrients
Volume number 9
Issue number 2
Article ID 122
Start page 1
End page 17
Total pages 17
Publisher MDPI
Place of publication Basel, Switzerland
Publication date 2017-02-09
ISSN 2072-6643
Keyword(s) sperm
fertility
nutrition
Animals
Blood Glucose
Cellular Reprogramming
Cellular Reprogramming Techniques
Diet, High-Fat
Fathers
Fatty Acids, Nonesterified
Female
Insulin
Islets of Langerhans
Male
Mice
Mice, Inbred C57BL
MicroRNAs
Obesity
Paternal Inheritance
Physical Conditioning, Animal
 fertility
 nutrition
Science & Technology
Life Sciences & Biomedicine
Nutrition & Dietetics
HIGH-FAT DIET
TRANSFER-RNA FRAGMENTS
PATERNAL OBESITY
METABOLIC SYNDROME
ADIPOSE-TISSUE
HEALTH
ALTERS
FERTILIZATION
INHERITANCE
GENERATIONS
Summary Paternal obesity programs metabolic syndrome in offspring. Low impact exercise in obese  males improves the metabolic health of female offspring, however whether this occurred in male  offspring remained unknown. C57BL/6NHsd (Harlan) mice were fed a control diet (CD; 6% fat, n =  7) or a high-fat diet (HFD; 21% fat, n = 16) for 18 weeks. After 9 weeks, HFD-fed mice either remained  sedentary (HH, n = 8) or undertook low-moderate exercise (HE, n = 8) for another 9 weeks. Male  offspring were assessed for glucose/insulin tolerance, body composition, plasma lipids, pancreatic  islet cell morphology and microRNA expression. Founder HH induced glucose intolerance, insulin  insensitivity, and hyperlipidaemia in male offspring (p < 0.05). Metabolic health was fully restored  in male offspring by founder exercise to control levels. Founder HH reduced pancreatic β-cell area  and islet cell size in male offspring, and altered the expression of 13 pancreatic microRNAs (p <  0.05). Founder HE led to partial restoration of pancreatic islet cell morphology and the expression  of two pancreatic microRNAs (let7d-5p, 194-5p) in male offspring. Founder HE reduced male  offspring adiposity, increased muscle mass, reduced plasma free fatty acids (FFAs), and further  altered pancreatic microRNAs (35 vs. HH; 32 vs. CD) (p < 0.05). Low-impact exercise in obese fathers  prior to conception, without dietary change, may be a viable intervention strategy to reduce the illeffects of obesity-induced paternal programming in male offspring.
Language eng
DOI 10.3390/nu9020122
Indigenous content off
Field of Research 1111 Nutrition And Dietetics
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2017 by the authors
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30116824

Document type: Journal Article
Collections: Office of the Deputy Vice-Chancellor (Research)
Open Access Collection
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.