A divergent hepatitis D-like agent in birds

Wille, Michelle, Netter, Hans J., Littlejohn, Margaret, Yuen, Lilly, Shi, Mang, Eden, John-Sebastian, Klaassen, Marcel, Holmes, Edward C. and Hurt, Aeron C. 2018, A divergent hepatitis D-like agent in birds, Viruses, vol. 10, no. 12, doi: 10.3390/v10120720.

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Title A divergent hepatitis D-like agent in birds
Author(s) Wille, Michelle
Netter, Hans J.
Littlejohn, Margaret
Yuen, Lilly
Shi, Mang
Eden, John-Sebastian
Klaassen, MarcelORCID iD for Klaassen, Marcel orcid.org/0000-0003-3907-9599
Holmes, Edward C.
Hurt, Aeron C.
Journal name Viruses
Volume number 10
Issue number 12
Publisher MDPI
Place of publication Basel, Switzerland
Publication date 2018-12-17
ISSN 1999-4915
Keyword(s) co-evolution
dabbling duck
hepatitis D virus
Science & Technology
Life Sciences & Biomedicine
Summary Hepatitis delta virus (HDV) is currently only found in humans and is a satellite virus that depends on hepatitis B virus (HBV) envelope proteins for assembly, release, and entry. Using meta-transcriptomics, we identified the genome of a novel HDV-like agent in ducks. Sequence analysis revealed secondary structures that were shared with HDV, including self-complementarity and ribozyme features. The predicted viral protein shares 32% amino acid similarity to the small delta antigen of HDV and comprises a divergent phylogenetic lineage. The discovery of an avian HDV-like agent has important implications for the understanding of the origins of HDV and sub-viral agents.
Language eng
DOI 10.3390/v10120720
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Grant ID DP160102146
Copyright notice ©2018, The Authors
Persistent URL http://hdl.handle.net/10536/DRO/DU:30117146

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