Toward precision psychiatry in bipolar disorder: staging 2.0

Salagre, Estela, Dodd, Seetal, Aedo, Alberto, Rosa, Adriane, Amoretti, Silvia, Pinzon, Justo, Reinares, Maria, Berk, Michael, Kapczinski, Flavio Pereira, Vieta, Eduard and Grande, Iria 2018, Toward precision psychiatry in bipolar disorder: staging 2.0, Frontiers in psychiatry, vol. 9, pp. 1-15, doi: 10.3389/fpsyt.2018.00641.

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Title Toward precision psychiatry in bipolar disorder: staging 2.0
Author(s) Salagre, Estela
Dodd, SeetalORCID iD for Dodd, Seetal
Aedo, Alberto
Rosa, Adriane
Amoretti, Silvia
Pinzon, Justo
Reinares, Maria
Berk, MichaelORCID iD for Berk, Michael
Kapczinski, Flavio Pereira
Vieta, Eduard
Grande, Iria
Journal name Frontiers in psychiatry
Volume number 9
Article ID 641
Start page 1
End page 15
Total pages 15
Publisher Frontiers Media
Place of publication Lausanne, Switzerland
Publication date 2018-11
ISSN 1664-0640
Keyword(s) biomarkers
bipolar disorder
personalized psychiatry
Science & Technology
Life Sciences & Biomedicine
Summary Personalized treatment is defined as choosing the "right treatment for the right person at the right time." Although psychiatry has not yet reached this level of precision, we are on the way thanks to recent technological developments that may aid to detect plausible molecular and genetic markers. At the moment there are some models that are contributing to precision psychiatry through the concept of staging. While staging was initially presented as a way to categorize patients according to clinical presentation, course, and illness severity, current staging models integrate multiple levels of information that can help to define each patient's characteristics, severity, and prognosis in a more precise and individualized way. Moreover, staging might serve as the foundation to create a clinical decision-making algorithm on the basis of the patient's stage. In this review we will summarize the evolution of the bipolar disorder staging model in relation to the new discoveries on the neurobiology of bipolar disorder. Furthermore, we will discuss how the latest and future progress in psychiatry might transform current staging models into precision staging models.
Language eng
DOI 10.3389/fpsyt.2018.00641
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2018, Salagre, Dodd, Aedo, Rosa, Amoretti, Pinzon, Reinares, Berk, Kapczinski, Vieta and Grande
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