Selenium status is not associated with cognitive performance: a cross-sectional study in 154 older Australian adults

Rita Cardoso, Barbara, Szymlek-Gay, Ewa A, Roberts, Blaine R, Formica, Melissa Brooke, Gianoudis, Jenny, O'Connell, Stella, Nowson, Caryl and Daly, Robin 2018, Selenium status is not associated with cognitive performance: a cross-sectional study in 154 older Australian adults, Nutrients, vol. 10, no. 12, pp. 1-12, doi: 10.3390/nu10121847.

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Title Selenium status is not associated with cognitive performance: a cross-sectional study in 154 older Australian adults
Author(s) Rita Cardoso, BarbaraORCID iD for Rita Cardoso, Barbara orcid.org/0000-0002-6393-1377
Szymlek-Gay, Ewa AORCID iD for Szymlek-Gay, Ewa A orcid.org/0000-0002-6533-7945
Roberts, Blaine R
Formica, Melissa Brooke
Gianoudis, Jenny
O'Connell, Stella
Nowson, CarylORCID iD for Nowson, Caryl orcid.org/0000-0001-6586-7965
Daly, RobinORCID iD for Daly, Robin orcid.org/0000-0002-9897-1598
Journal name Nutrients
Volume number 10
Issue number 12
Article ID 1847
Start page 1
End page 12
Total pages 12
Publisher MDPI
Place of publication Basel, Switzerland
Publication date 2018-12
ISSN 2072-6643
Keyword(s) selenium
cognition
dementia
inflammatory markers
neurotrophic factors
brain-derived neurotrophic factor
cognitive dysfunction
cytokines
inflammation
nutritional status
science & technology
life sciences & biomedicine
nutrition & dietetics
Summary Selenium was suggested to play a role in modulating cognitive performance and dementia risk. Thus, this study aimed to investigate the association between selenium status and cognitive performance, as well as inflammatory and neurotrophic markers in healthy older adults. This cross-sectional study included 154 older adults (≥60 years) from Victoria, Australia. Participants were assessed for cognitive performance (Cogstate battery), dietary selenium intake (two 24-h food recalls), plasma selenium concentration, inflammatory markers (interleukin (IL)-6, -8, -10, tumor necrosis factor-alpha and adiponectin) and neurotrophic factors (brain-derived neurotrophic factor, vascular endothelial growth factor and insulin-like growth factor 1). Dietary selenium intake was adequate for 85% of all participants. The prevalence of selenium deficiency was low; only 8.4% did not have the minimum concentration in plasma required for optimization of iodothyronine 5' deiodinases activity. Multiple linear regression analysis revealed that plasma selenium was not associated with cognitive performance, inflammatory markers nor neurotrophic factors, independent of age, sex, body mass index (BMI), habitual physical activity, APOE status, education, and history of cardiovascular disease. The lack of association might be due to the optimization of selenoproteins synthesis as a result of adequate selenium intake. Future prospective studies are recommended to explore potential associations of selenium status with age-associated cognitive decline.
Language eng
DOI 10.3390/nu10121847
Field of Research 1111 Nutrition And Dietetics
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2018, the authors
Persistent URL http://hdl.handle.net/10536/DRO/DU:30117290

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