Investigating nutrition-related complications and quality of life in patients with gastroenteropancreatic neuroendocrine tumors: protocol for a mixed-methods prospective study

Laing, Erin, Kiss, Nicole, Michael, Michael, Gough, Karla and Krishnasamy, Meinir 2018, Investigating nutrition-related complications and quality of life in patients with gastroenteropancreatic neuroendocrine tumors: protocol for a mixed-methods prospective study, JMIR research protocols, vol. 7, no. 12, doi: 10.2196/11228.

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Title Investigating nutrition-related complications and quality of life in patients with gastroenteropancreatic neuroendocrine tumors: protocol for a mixed-methods prospective study
Author(s) Laing, Erin
Kiss, NicoleORCID iD for Kiss, Nicole orcid.org/0000-0002-6476-9834
Michael, Michael
Gough, Karla
Krishnasamy, Meinir
Journal name JMIR research protocols
Volume number 7
Issue number 12
Article ID e11228
Total pages 10
Publisher JMIR Publications
Place of publication Toronto, Ont.
Publication date 2018-12-19
ISSN 1929-0748
Keyword(s) diet
diet, food, and nutrition
malnutrition
neuroendocrine tumor
niacin
patient experience
signs and symptoms
vitamins
Summary BACKGROUND: Gastroenteropancreatic neuroendocrine tumors (GEP NETs) are a heterogeneous group of tumors with distinct effects on the body due to their potential to secrete hormones and peptides. The incidence and prevalence of GEP NETs in Australia are rising. During 2000-2006, the annual incidence was approximately 3.3 per 100,000 population. To date, there has been development of clinical practice and consensus guidelines for NETs covering best practice for diagnosis, treatment, and medical management; however, the supportive care needs and optimal nutritional management of patients affected by NETs remains underresearched, and evidence to guide clinical practice is lacking. While there is emerging research describing the extent of morbidity in different types of GEP NET patients, little is known about the experience of people affected by these tumors and how nutritional status is impacted by either diagnosis or treatment. OBJECTIVE: The objective of this study was to explore nutrition-related complications and quality of life of patients diagnosed with a GEP NET and to generate evidence to inform future research and development of nutrition screening and management practices. METHODS: Patients diagnosed with a GEP NET at two metropolitan recruitment sites will be invited to participate in a 6-month, mixed-methods longitudinal study. Participants recruited to the study will receive usual care and participate in data collection for the study at 4 time points (at recruitment and 2, 4, and 6 months postrecruitment). Study data will include nutritional status, body weight, fat-free mass, and patient-reported outcome measures (dietitian contact, disease-related symptom presence and severity, dietary habits, health-related quality of life, psychological morbidity, and financial impact). At recruitment and 6 months postrecruitment, complete nutrient testing, including relevant plasma vitamin levels, will also be undertaken. A purposive sample of participants will be invited to take part in semistructured interviews to explore the experience of living with a GEP NET and associated nutrition complications. RESULTS: Ethics approval has been obtained, and study recruitment and data collection are underway. CONCLUSIONS: This study will provide the first in-depth, comprehensive description of nutritional issues in patients with GEP NETs. Results will advance the knowledge of nutritional issues faced by patients with GEP NETs and help inform the development of screening tools and clinical practice guidelines. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/11228.
Language eng
DOI 10.2196/11228
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2018, Erin Laing, Nicole Kiss, Michael Michael, Karla Gough, Meinir Krishnasamy
Persistent URL http://hdl.handle.net/10536/DRO/DU:30117443

Document type: Journal Article
Collections: School of Life and Environmental Sciences
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