Pyruvate suppresses PGC1alpha expression and substrate utilization despite increased respiratory chain content in C2C12 myotubes

Philp, Andrew, Perez-Schindler, Joaquin, Green, Charlotte, Hamilton, D. Lee and Baar, Keith 2010, Pyruvate suppresses PGC1alpha expression and substrate utilization despite increased respiratory chain content in C2C12 myotubes, American journal of physiology. Cell physiology, vol. 299, no. 2, pp. C240-C250, doi: 10.1152/ajpcell.00438.2009.

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Title Pyruvate suppresses PGC1alpha expression and substrate utilization despite increased respiratory chain content in C2C12 myotubes
Author(s) Philp, Andrew
Perez-Schindler, Joaquin
Green, Charlotte
Hamilton, D. LeeORCID iD for Hamilton, D. Lee orcid.org/0000-0002-5620-4788
Baar, Keith
Journal name American journal of physiology. Cell physiology
Volume number 299
Issue number 2
Start page C240
End page C250
Total pages 11
Publisher American Physiological Society
Place of publication Bethesda, Md.
Publication date 2010-08
ISSN 0363-6143
1522-1563
Keyword(s) Animals
Cell Line
Cells, Cultured
Citric Acid Cycle
Down-Regulation
Electron Transport
Mice
Muscle Fibers, Skeletal
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
Pyruvic Acid
Substrate Specificity
Trans-Activators
Transcription Factors
Up-Regulation
Science & Technology
Life Sciences & Biomedicine
Cell Biology
Physiology
glutamine
glucose metabolism
Type 2 diabetes
peroxisome proliferator-activated receptor-gamma coactivator-1 alpha
ACTIVATED PROTEIN-KINASE
SKELETAL-MUSCLE CELLS
MITOCHONDRIAL BIOGENESIS
PGC-1-RELATED COACTIVATOR
INSULIN-RESISTANCE
MAMMALIAN-CELLS
GENE-EXPRESSION
EXERCISE
PGC-1-ALPHA
AMPK
Language eng
DOI 10.1152/ajpcell.00438.2009
Field of Research 0601 Biochemistry And Cell Biology
0606 Physiology
1116 Medical Physiology
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2010, American Physiological Society
Persistent URL http://hdl.handle.net/10536/DRO/DU:30117933

Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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