Development of a miniature device for emerging deep brain stimulation paradigms

Adams, Scott D, Bennet, Kevin E, Tye, Susannah J, Berk, Michael and Kouzani, Abbas Z 2019, Development of a miniature device for emerging deep brain stimulation paradigms, PLoS one, vol. 14, no. 2, pp. 1-17, doi: 10.1371/journal.pone.0212554.

Attached Files
Name Description MIMEType Size Downloads

Title Development of a miniature device for emerging deep brain stimulation paradigms
Author(s) Adams, Scott D
Bennet, Kevin E
Tye, Susannah J
Berk, MichaelORCID iD for Berk, Michael
Kouzani, Abbas ZORCID iD for Kouzani, Abbas Z
Journal name PLoS one
Volume number 14
Issue number 2
Article ID e0212554
Start page 1
End page 17
Total pages 17
Publisher Public Library of Science
Place of publication San Francisco, Calif.
Publication date 2019
ISSN 1932-6203
Keyword(s) Functional electrical stimulation
Electrical circuits
Deep-brain stimulation
Medical devices and equipment
User interfaces
Brain damage
Science & Technology
Multidisciplinary Sciences
Summary Deep brain stimulation (DBS) is a neuromodulatory approach for treatment of several neurological and psychiatric disorders. A new focus on optimising the waveforms used for stimulation is emerging regarding the mechanism of DBS treatment. Many existing DBS devices offer only a limited set of predefined waveforms, mainly rectangular, and hence are inapt for exploring the emerging paradigm. Advances in clinical DBS are moving towards incorporating new stimulation parameters, yet we remain limited in our capacity to test these in animal models, arguably a critical first step. Accordingly, there is a need for the development of new miniature, low-power devices to enable investigation into the new DBS paradigms in preclinical settings. The ideal device would allow for flexibility in the stimulation waveforms, while remaining suitable for chronic, tetherless, biphasic deep brain stimulation. In this work, we elucidate several key parameters in a DBS system, identify gaps in existing solutions, and propose a new device to support preclinical DBS. The device allows for a high degree of flexibility in the output waveform with easily altered shape, frequency, pulse-width and amplitude. The device is suitable for both traditional and modern stimulation schemes, including those using non-rectangular waveforms, as well as delayed feedback schemes. The device incorporates active charge balancing to ensure safe operation, and allows for simple production of custom biphasic waveforms. This custom waveform output is unique in the field of preclinical DBS devices, and could be advantageous in performing future DBS studies investigating new treatment paradigms. This tetherless device can be easily and comfortably carried by an animal in a back-mountable configuration. The results of in-vitro tests are presented and discussed.
Language eng
DOI 10.1371/journal.pone.0212554
Field of Research 110999 Neurosciences not elsewhere classified
110319 Psychiatry (incl Psychotherapy)
MD Multidisciplinary
Socio Economic Objective 920410 Mental Health
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2019, Adams et al.
Persistent URL

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
Open Access Checking
Connect to link resolver
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 0 times in TR Web of Science
Scopus Citation Count Cited 0 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 102 Abstract Views, 0 File Downloads  -  Detailed Statistics
Created: Wed, 27 Feb 2019, 11:47:15 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact