Epigenetic silencing of BIM in glucocorticoid poor-responsive pediatric acute lymphoblastic leukemia, and its reversal by histone deacetylase inhibition

Bachmann, Petra S, Piazza, Rocco G, Janes, Mary E, Wong, Nicholas C, Davies, Carwyn, Mogavero, Angela, Bhadri, Vivek A, Szymanska, Barbara, Geninson, Greta, Magistroni, Vera, Cazzaniga, Giovanni, Biondi, Andrea, Miranda-Saavedra, Diego, Göttgens, Berthold, Saffery, Richard, Craig, Jeffrey M, Marshall, Glenn M, Gambacorti-Passerini, Carlo, Pimanda, John E and Lock, Richard B 2010, Epigenetic silencing of BIM in glucocorticoid poor-responsive pediatric acute lymphoblastic leukemia, and its reversal by histone deacetylase inhibition, Blood, vol. 116, no. 16, pp. 3013-3022, doi: 10.1182/blood-2010-05-284968.

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Title Epigenetic silencing of BIM in glucocorticoid poor-responsive pediatric acute lymphoblastic leukemia, and its reversal by histone deacetylase inhibition
Author(s) Bachmann, Petra S
Piazza, Rocco G
Janes, Mary E
Wong, Nicholas C
Davies, Carwyn
Mogavero, Angela
Bhadri, Vivek A
Szymanska, Barbara
Geninson, Greta
Magistroni, Vera
Cazzaniga, Giovanni
Biondi, Andrea
Miranda-Saavedra, Diego
Göttgens, Berthold
Saffery, Richard
Craig, Jeffrey MORCID iD for Craig, Jeffrey M orcid.org/0000-0003-3979-7849
Marshall, Glenn M
Gambacorti-Passerini, Carlo
Pimanda, John E
Lock, Richard B
Journal name Blood
Volume number 116
Issue number 16
Start page 3013
End page 3022
Total pages 10
Publisher American Society of Hematology
Place of publication Washington, D.C.
Publication date 2010-10-21
ISSN 1528-0020
Keyword(s) Animals
Antineoplastic Agents
Antineoplastic Agents, Hormonal
Apoptosis Regulatory Proteins
Bcl-2-Like Protein 11
Child
Dexamethasone
Drug Resistance, Neoplasm
Gene Silencing
Genetic Loci
Glucocorticoids
Histone Deacetylase Inhibitors
Histone Deacetylases
Humans
Hydroxamic Acids
Membrane Proteins
Mice
Mice, SCID
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Proto-Oncogene Proteins
Vorinostat
Science & Technology
Life Sciences & Biomedicine
Hematology
Language eng
DOI 10.1182/blood-2010-05-284968
Field of Research 1102 Cardiovascular Medicine And Haematology
1103 Clinical Sciences
1114 Paediatrics And Reproductive Medicine
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2010, The American Society of Hematology
Persistent URL http://hdl.handle.net/10536/DRO/DU:30119163

Document type: Journal Article
Collection: School of Medicine
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