Increased perseverative errors following high-definition transcranial direct current stimulation over the ventrolateral cortex during probabilistic reversal learning

Albein-Urios, Natalia, Chase, Henry, Clark, Luke, Kirkovski, Melissa, Davies, Charlotte and Enticott, Peter 2019, Increased perseverative errors following high-definition transcranial direct current stimulation over the ventrolateral cortex during probabilistic reversal learning, Brain stimulation, doi: 10.1016/j.brs.2019.02.013.

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Title Increased perseverative errors following high-definition transcranial direct current stimulation over the ventrolateral cortex during probabilistic reversal learning
Author(s) Albein-Urios, NataliaORCID iD for Albein-Urios, Natalia orcid.org/0000-0001-7841-018X
Chase, Henry
Clark, Luke
Kirkovski, MelissaORCID iD for Kirkovski, Melissa orcid.org/0000-0003-3395-8525
Davies, Charlotte
Enticott, PeterORCID iD for Enticott, Peter orcid.org/0000-0002-6638-951X
Journal name Brain stimulation
Total pages 8
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2019-02-21
ISSN 1876-4754
Keyword(s) Cathodal stimulation
Feedback-related negativity
High-definition transcranial direct current stimulation
Perseverative errors
Probabilistic reversal learning
Ventrolateral prefrontal cortex
Summary BACKGROUND: The prefrontal cortex regulates behavioural adaptation in response to feedback. However, the causal role of different prefrontal regions remains unclear, based on indirect evidence derived from functional neuroimaging. Neuroimaging studies show dorsomedial prefrontal activation during feedback monitoring, whereas the ventrolateral prefrontal cortex engages during behavioural adaptation (shifting). OBJECTIVE: We used high-definition transcranial direct current stimulation (HD-tDCS) to elucidate the roles of the ventrolateral prefrontal cortex (vlPFC) and the dorsomedial prefrontal cortex (dmPFC) in behaviour change, using a probabilistic reversal learning task (PRLT). METHOD: Fifty-two healthy adults were randomly assigned to receive cathodal HD-tDCS to inhibit the vlPFC or the dmPFC versus sham stimulation, prior to completing the PRLT. The outcome measures were the number of perseverative errors and the electroencephalography (EEG) signals of feedback-related negativity (FRN) in the PRLT. We hypothesised that inhibition of the vlPFC would be specifically associated with more perseverative errors and weaker FRNs. RESULTS: We found that vlPFC inhibition was associated with higher perseverative errors compared to sham and dmPFC stimulation conditions. Although there were no statistically significant differences in FRN amplitudes, the effect sizes indicate an association between inhibition of the vlPFC and lower FRN amplitudes. CONCLUSION: Our findings support a causal role of the vlPFC on feedback-based behavioural adaptation, which is critical for adaptive goal-driven behaviour.
Notes In Press
Language eng
DOI 10.1016/j.brs.2019.02.013
Field of Research 11 Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2019, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30119330

Document type: Journal Article
Collection: School of Psychology
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