The bioavailability of eicosapentaenoic acid from reconstituted triglyceride fish oil is higher than that obtained from the triglyceride and monoglyceride forms

Wakil, Ammar, Mir, Miquel, Mellor, Duane D., Mellor, Stephen F. and Atkin, Stephen L. 2010, The bioavailability of eicosapentaenoic acid from reconstituted triglyceride fish oil is higher than that obtained from the triglyceride and monoglyceride forms, Asia Pacific journal of clinical nutrition, vol. 19, no. 4, pp. 499-505.

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Title The bioavailability of eicosapentaenoic acid from reconstituted triglyceride fish oil is higher than that obtained from the triglyceride and monoglyceride forms
Author(s) Wakil, Ammar
Mir, Miquel
Mellor, Duane D.ORCID iD for Mellor, Duane D. orcid.org/0000-0001-5007-5906
Mellor, Stephen F.
Atkin, Stephen L.
Journal name Asia Pacific journal of clinical nutrition
Volume number 19
Issue number 4
Start page 499
End page 505
Total pages 7
Publisher HEC Press
Place of publication Clayton, Vic.
Publication date 2010-12
ISSN 0964-7058
Keyword(s) Adult
Area Under Curve
Biological Availability
Cross-Over Studies
Dietary Supplements
Double-Blind Method
Eicosapentaenoic Acid
Female
Fish Oils
Humans
Male
Monoglycerides
Reference Values
Triglycerides
Summary Omega 3 fatty acids have healthcare benefits, but their absorption characteristics are not well defined, particularly for strategies to improve their bioavailability. We performed a double blind study comparing the bioavailability of 20% eicosapentaenoic acid in 4.5 grams of: natural triglyceride, reconstituted triglyceride, enzymatically synthesized triglyceride, monoglyceride and diglyceride. Seven healthy volunteers were given the supplements on five occasions while repeated measurements of eicosapentaenoic acid were taken to calculate the area under the curve for the next 24 hours. There was a significant difference between the mean of calculated area under the curve of eicosapentaenoic acid from reconstituted triglyceride (30.2) and that of the enzymatically synthesized triglyceride (11.9) and monoglyceride (13.4), z=-2.36 and -2.19, respectively, p<0.05. In summary, eicosapentaenoic acid bioavailability of chemically reconstituted triglycerides was better than that obtained from enzymatically synthesized triglyceride and monoglyceride.
Language eng
Field of Research 1111 Nutrition And Dietetics
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2010, HEC Press
Persistent URL http://hdl.handle.net/10536/DRO/DU:30119471

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