Distinct gut virome profile of pregnant women with type 1 diabetes in the ENDIA study

Wook Kim, Ki, Allen, Digby W, Briese, Thomas, Couper, Jennifer J, Barry, Simon C, Colman, Peter G, Cotterill, Andrew M, Davis, Elizabeth A, Giles, Lynne C, Harrison, Leonard C, Harris, Mark, Haynes, Aveni, Horton, Jessica L, Isaacs, Sonia R, Jain, Komal, Lipkin, Walter Ian, Morahan, Grant, Morbey, Claire, Pang, Ignatius CN, Papenfuss, Anthony T, Penno, Megan AS, Sinnott, Richard O, Soldatos, Georgia, Thomson, Rebecca L, Vuillermin, Peter J, Wentworth, John M, Wilkins, Marc R, Rawlinson, William D, Craig, Maria E and ENDIA Study Group 2019, Distinct gut virome profile of pregnant women with type 1 diabetes in the ENDIA study, Open forum infectious diseases, vol. 6, no. 2, pp. 1-8, doi: 10.1093/ofid/ofz025.

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Title Distinct gut virome profile of pregnant women with type 1 diabetes in the ENDIA study
Author(s) Wook Kim, Ki
Allen, Digby W
Briese, Thomas
Couper, Jennifer J
Barry, Simon C
Colman, Peter G
Cotterill, Andrew M
Davis, Elizabeth A
Giles, Lynne C
Harrison, Leonard C
Harris, Mark
Haynes, Aveni
Horton, Jessica L
Isaacs, Sonia R
Jain, Komal
Lipkin, Walter Ian
Morahan, Grant
Morbey, Claire
Pang, Ignatius CN
Papenfuss, Anthony T
Penno, Megan AS
Sinnott, Richard O
Soldatos, Georgia
Thomson, Rebecca L
Vuillermin, Peter JORCID iD for Vuillermin, Peter J orcid.org/0000-0002-6580-0346
Wentworth, John M
Wilkins, Marc R
Rawlinson, William D
Craig, Maria E
ENDIA Study Group
Journal name Open forum infectious diseases
Volume number 6
Issue number 2
Article ID ofz025
Start page 1
End page 8
Total pages 8
Publisher Oxford University Press
Place of publication Oxford, Eng.
Publication date 2019-02
ISSN 2328-8957
Keyword(s) enterovirus
pregnancy
type 1 diabetes
virome capture sequencing
ENDIA Study Group
Science & Technology
Life Sciences & Biomedicine
Immunology
Infectious Diseases
Microbiology
Summary Background: The importance of gut bacteria in human physiology, immune regulation, and disease pathogenesis is well established. In contrast, the composition and dynamics of the gut virome are largely unknown; particularly lacking are studies in pregnancy. We used comprehensive virome capture sequencing to characterize the gut virome of pregnant women with and without type 1 diabetes (T1D), longitudinally followed in the Environmental Determinants of Islet Autoimmunity study. Methods: In total, 61 pregnant women (35 with T1D and 26 without) from Australia were examined. Nucleic acid was extracted from serial fecal specimens obtained at prenatal visits, and viral genomes were sequenced by virome capture enrichment. The frequency, richness, and abundance of viruses were compared between women with and without T1D. Results: Two viruses were more prevalent in pregnant women with T1D: picobirnaviruses (odds ratio [OR], 4.2; 95% confidence interval [CI], 1.0-17.1; P = .046) and tobamoviruses (OR, 3.2; 95% CI, 1.1-9.3; P = .037). The abundance of 77 viruses significantly differed between the 2 maternal groups (≥2-fold difference; P < .02), including 8 Enterovirus B types present at a higher abundance in women with T1D. Conclusions: These findings provide novel insight into the composition of the gut virome during pregnancy and demonstrate a distinct profile of viruses in women with T1D.
Language eng
DOI 10.1093/ofid/ofz025
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2019, The Author(s)
Persistent URL http://hdl.handle.net/10536/DRO/DU:30119696

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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