Exercise and mitochondrial dynamics: keeping in shape with ROS and AMPK

Trewin, Adam J., Berry, Brandon J. and Wojtovich, Andrew P. 2018, Exercise and mitochondrial dynamics: keeping in shape with ROS and AMPK, Antioxidants, vol. 7, no. 1, doi: 10.3390/antiox7010007.

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Title Exercise and mitochondrial dynamics: keeping in shape with ROS and AMPK
Author(s) Trewin, Adam J.ORCID iD for Trewin, Adam J. orcid.org/0000-0001-7322-4054
Berry, Brandon J.
Wojtovich, Andrew P.
Journal name Antioxidants
Volume number 7
Issue number 1
Total pages 21
Publisher MDPI Publishing
Place of publication Basel, Switzerland
Publication date 2018-01-06
ISSN 2076-3921
Keyword(s) dynamics
energetics
exercise
mitochondria
oxidative stress
reactive oxygen species
redox signaling
Science & Technology
Life Sciences & Biomedicine
Biochemistry & Molecular Biology
Chemistry, Medicinal
Food Science & Technology
Pharmacology & Pharmacy
ACTIVATED PROTEIN-KINASE
HUMAN SKELETAL-MUSCLE
REACTIVE OXYGEN
HYDROGEN-PEROXIDE
INNER MEMBRANE
ANTIOXIDANT RESPONSE
OPTOGENETIC CONTROL
SIGNALING PATHWAYS
POSITION STATEMENT
COMPLEX-II
Summary Exercise is a robust stimulus for mitochondrial adaptations in skeletal muscle which consequently plays a central role in enhancing metabolic health. Despite this, the precise molecular events that underpin these beneficial effects remain elusive. In this review, we discuss molecular signals generated during exercise leading to altered mitochondrial morphology and dynamics. In particular, we focus on the interdependence between reactive oxygen species (ROS) and redox homeostasis, the sensing of cellular bioenergetic status via 5' adenosine monophosphate (AMP)-activated protein kinase (AMPK), and the regulation of mitochondrial fission and fusion. Precisely how exercise regulates the network of these responses and their effects on mitochondrial dynamics is not fully understood at present. We highlight the limitations that exist with the techniques currently available, and discuss novel molecular tools to potentially advance the fields of redox biology and mitochondrial bioenergetics. Ultimately, a greater understanding of these processes may lead to novel mitochondria-targeted therapeutic strategies to augment or mimic exercise in order to attenuate or reverse pathophysiology.
Language eng
DOI 10.3390/antiox7010007
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2018, The Authors
Persistent URL http://hdl.handle.net/10536/DRO/DU:30119826

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