The therapeutic potential of mangosteen pericarp as an adjunctive therapy for bipolar disorder and schizophrenia

Ashton, Melanie M, Dean, Olivia M, Walker, Adam J, Bortolasci, Chiara C, Ng, Chee H, Hopwood, Malcolm, Harvey, Brian H, Möller, Marisa, McGrath, John J, Marx, Wolfgang, Turner, Alyna, Dodd, Seetal, Scott, James G, Khoo, Jon-Paul, Walder, Ken, Sarris, Jerome and Berk, Michael 2019, The therapeutic potential of mangosteen pericarp as an adjunctive therapy for bipolar disorder and schizophrenia, Frontiers in psychiatry, vol. 10, pp. 1-17, doi: 10.3389/fpsyt.2019.00115.

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Title The therapeutic potential of mangosteen pericarp as an adjunctive therapy for bipolar disorder and schizophrenia
Author(s) Ashton, Melanie MORCID iD for Ashton, Melanie M orcid.org/0000-0001-6832-4157
Dean, Olivia MORCID iD for Dean, Olivia M orcid.org/0000-0002-2776-3935
Walker, Adam JORCID iD for Walker, Adam J orcid.org/0000-0002-5399-1245
Bortolasci, Chiara CORCID iD for Bortolasci, Chiara C orcid.org/0000-0002-0794-6363
Ng, Chee H
Hopwood, Malcolm
Harvey, Brian H
Möller, Marisa
McGrath, John J
Marx, Wolfgang
Turner, AlynaORCID iD for Turner, Alyna orcid.org/0000-0001-7389-2546
Dodd, SeetalORCID iD for Dodd, Seetal orcid.org/0000-0002-7918-4636
Scott, James G
Khoo, Jon-Paul
Walder, Ken
Sarris, Jerome
Berk, MichaelORCID iD for Berk, Michael orcid.org/0000-0002-5554-6946
Journal name Frontiers in psychiatry
Volume number 10
Article ID 115
Start page 1
End page 17
Total pages 17
Publisher Frontiers Media
Place of publication Lausanne, Switzerland
Publication date 2019-03
ISSN 1664-0640
Keyword(s) bipolar disorder
inflammation
mangosteen pericarp
mitochondria
oxidative stress
psychiatry
schizophrenia
Science & Technology
Life Sciences & Biomedicine
Summary New treatments are urgently needed for serious mental illnesses including bipolar disorder and schizophrenia. This review proposes that Garcinia mangostana Linn. (mangosteen) pericarp is a possible adjunctive therapeutic agent for these disorders. Research to date demonstrates that neurobiological properties of the mangosteen pericarp are well aligned with the current understanding of the pathophysiology of bipolar disorder and schizophrenia. Mangosteen pericarp has antioxidant, putative neuroprotective, anti-inflammatory, and putative mitochondrial enhancing properties, with animal studies demonstrating favorable pharmacotherapeutic benefits with respect to these disorders. This review summarizes evidence of its properties and supports the case for future studies to assess the utility of mangosteen pericarp as an adjunctive treatment option for mood and psychotic disorders.
Language eng
DOI 10.3389/fpsyt.2019.00115
Field of Research 110999 Neurosciences not elsewhere classified
Socio Economic Objective 920199 Clinical Health (Organs
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2019, Ashton, Dean, Walker, Bortolasci, Ng, Hopwood, Harvey, Möller, McGrath, Marx, Turner, Dodd, Scott, Khoo, Walder, Sarris and Berk
Persistent URL http://hdl.handle.net/10536/DRO/DU:30120251

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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