Nutraceuticals and nutritional supplements for the treatment of bipolar disorder: protocol for a systematic review

Ashton, Melanie, Berk, Michael, Ng, Chee H., Hopwood, Malcolm, Kavanagh, Bianca, Williams, Lana, Sarris, Jerome and Dean, Olivia 2019, Nutraceuticals and nutritional supplements for the treatment of bipolar disorder: protocol for a systematic review, BMJ Open, vol. 9, no. 4, doi: 10.1136/bmjopen-2018-025640.

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Title Nutraceuticals and nutritional supplements for the treatment of bipolar disorder: protocol for a systematic review
Author(s) Ashton, MelanieORCID iD for Ashton, Melanie orcid.org/0000-0001-6832-4157
Berk, MichaelORCID iD for Berk, Michael orcid.org/0000-0002-5554-6946
Ng, Chee H.
Hopwood, Malcolm
Kavanagh, BiancaORCID iD for Kavanagh, Bianca orcid.org/0000-0002-1656-2775
Williams, LanaORCID iD for Williams, Lana orcid.org/0000-0002-1377-1272
Sarris, Jerome
Dean, OliviaORCID iD for Dean, Olivia orcid.org/0000-0002-2776-3935
Journal name BMJ Open
Volume number 9
Issue number 4
Article ID e025640
Total pages 5
Publisher BMJ Publishing Group
Place of publication London, Eng.
Publication date 2019-04
ISSN 2044-6055
Keyword(s) bipolar disorder
dietary supplement
nutraceutical
review
Summary INTRODUCTION: First line pharmacological treatments for bipolar disorder (BD) can leave shortfalls in recovery leading to patients seeking alternative and adjunctive treatments such as nutraceuticals. This protocol for a systematic review and proposed meta-analysis aims to answer the research question: in patients with BD, how does use of nutraceutical treatments compare with placebo in reducing depressive and mania symptoms? METHODS AND ANALYSIS: Clinical trials will be identified through database searches using PubMed via PubMed, EMBASE via embase.com, Cochrane Central Register of Controlled Clinical Trials (CENTRAL) via cochranelibrary.com and CINAHL Complete via EBSCO. Search terms for BD and specific nutraceuticals (75 total search terms) will be used. Double-blind, randomised, controlled, clinical trials of adults with BD will be included in the review. Risk of bias will be assessed using the Cochrane Collaboration's tool for assessing risk of bias in randomised trials. ETHICS AND DISSEMINATION: This review will only look at published data (already reviewed for ethical compliance); therefore, ethical approval is not required. We aim to publish the systematic review in a peer-reviewed journal and present at conferences. PROSPERO REGISTRATION NUMBER: CRD42019100745.
Language eng
DOI 10.1136/bmjopen-2018-025640
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2019, The Authors
Persistent URL http://hdl.handle.net/10536/DRO/DU:30120513

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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