Temporally controlled release of multiple growth factors from a self-assembling peptide hydrogel

Bruggeman, Kiara F, Rodriguez, Alexandra L, Parish, Clare L, Williams, Richard J and Nisbet, David R 2016, Temporally controlled release of multiple growth factors from a self-assembling peptide hydrogel, Nanotechnology, vol. 27, no. 38, pp. 1-7, doi: 10.1088/0957-4484/27/38/385102.

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Title Temporally controlled release of multiple growth factors from a self-assembling peptide hydrogel
Author(s) Bruggeman, Kiara F
Rodriguez, Alexandra L
Parish, Clare L
Williams, Richard JORCID iD for Williams, Richard J orcid.org/0000-0003-3831-8738
Nisbet, David R
Journal name Nanotechnology
Volume number 27
Issue number 38
Article ID 385102
Start page 1
End page 7
Total pages 7
Publisher IOP Publishing
Place of publication Bristol, Eng.
Publication date 2016-09-23
ISSN 1361-6528
Keyword(s) drug delivery
self-assembling peptide
tissue engineering
controlled release
Science & Technology
Physical Sciences
Nanoscience & Nanotechnology
Materials Science, Multidisciplinary
Physics, Applied
Materials Science
Summary Protein growth factors have demonstrated great potential for tissue repair, but their inherent instability and large size prevents meaningful presentation to biologically protected nervous tissue. Here, we create a nanofibrous network from a self-assembling peptide (SAP) hydrogel to carry and stabilize the growth factors. We significantly reduced growth factor degradation to increase their lifespan by over 40 times. To control the temporal release profile we covalently attached polysaccharide chitosan molecules to the growth factor to increase its interactions with the hydrogel nanofibers and achieved a 4 h delay, demonstrating the potential of this method to provide temporally controlled growth factor delivery. We also describe release rate based analysis to examine the growth factor delivery in more detail than standard cumulative release profiles allow and show that the chitosan attachment method provided a more consistent release profile with a 60% reduction in fluctuations. To prove the potential of this system as a complex growth factor delivery platform we demonstrate for the first time temporally distinct release of multiple growth factors from a single tissue specific SAP hydrogel: a significant goal in regenerative medicine.
Language eng
DOI 10.1088/0957-4484/27/38/385102
Field of Research MD Multidisciplinary
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2016, IOP Publishing Ltd
Persistent URL http://hdl.handle.net/10536/DRO/DU:30120617

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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