Statins and inflammation: new therapeutic opportunities in psychiatry

Kim, Sung-Wan, Kang, Hee-Ju, Jhon, Min, Kim, Ju-Wan, Lee, Ju-Yeon, Walker, Adam, Agustini, Bruno, Kim, Jae-Min and Berk, Michael 2019, Statins and inflammation: new therapeutic opportunities in psychiatry, Frontiers in psychiatry, vol. 10, doi: 10.3389/fpsyt.2019.00103.

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Title Statins and inflammation: new therapeutic opportunities in psychiatry
Author(s) Kim, Sung-Wan
Kang, Hee-Ju
Jhon, Min
Kim, Ju-Wan
Lee, Ju-Yeon
Walker, AdamORCID iD for Walker, Adam orcid.org/0000-0002-5399-1245
Agustini, Bruno
Kim, Jae-Min
Berk, MichaelORCID iD for Berk, Michael orcid.org/0000-0002-5554-6946
Journal name Frontiers in psychiatry
Volume number 10
Article ID 103
Total pages 16
Publisher Frontiers Media
Place of publication Lausanne, Switzerland
Publication date 2019-03
ISSN 1664-0640
Keyword(s) dementia
depression
inflammation
schizophrenia
statin
Science & Technology
Life Sciences & Biomedicine
Psychiatry
C-REACTIVE PROTEIN
MAJOR DEPRESSIVE DISORDER
LIPID-LOWERING DRUGS
N-ACETYL CYSTEINE
DOUBLE-BLIND
ALZHEIMERS-DISEASE
CHOLESTEROL LEVELS
COGNITIVE FUNCTION
CORONARY ATHEROSCLEROSIS
ANTIINFLAMMATORY AGENTS
Summary Statins, which are widely used to treat hypercholesterolemia, have anti-inflammatory and anti-oxidant effects. These are thought to be responsible for the potential effects of statins on various psychiatric disorders. In this study, we comprehensively review the literature to investigate the effects of statins on various psychiatric disorders including depression, schizophrenia, and dementia. In addition, we review adverse effects and drug interactions of statins to give clinically useful information guiding statin use in the psychiatric field. Statins seem useful in reducing depression, particularly in patients with physical disorders such as cardiovascular disease. In patients with schizophrenia, negative symptoms may be reduced by adjuvant statin therapy. Studies on cohorts at risk for dementia have generally shown protective effects of statins, while those on treatment for dementia show inconsistent results. In conclusion, statins used in combination with conventional psychotropic medications may be effective for various psychiatric disorders including depression, schizophrenia, and dementia. Further study is required to determine optimal doses and duration of statin use for the treatment of psychiatric disorders.
Language eng
DOI 10.3389/fpsyt.2019.00103
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2019, Kim, Kang, Jhon, Kim, Lee, Walker, Agustini, Kim and Berk.
Persistent URL http://hdl.handle.net/10536/DRO/DU:30120656

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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