Are office-based workplace interventions designed to reduce sitting time cost-effective primary prevention measures for cardiovascular disease? A systematic review and modelled economic evaluation

Gao, Lan, Nguyen, Kim Phuong, Dunstan, David and Moodie, Marjory 2019, Are office-based workplace interventions designed to reduce sitting time cost-effective primary prevention measures for cardiovascular disease? A systematic review and modelled economic evaluation, International journal of environmental research and public health, vol. 16, no. 5, doi: 10.3390/ijerph16050834.

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Title Are office-based workplace interventions designed to reduce sitting time cost-effective primary prevention measures for cardiovascular disease? A systematic review and modelled economic evaluation
Author(s) Gao, LanORCID iD for Gao, Lan orcid.org/0000-0001-9734-1140
Nguyen, Kim Phuong
Dunstan, David
Moodie, MarjoryORCID iD for Moodie, Marjory orcid.org/0000-0001-6890-5250
Journal name International journal of environmental research and public health
Volume number 16
Issue number 5
Total pages 17
Publisher MDPI
Place of publication Basel, Switzerland
Publication date 2019-03-07
ISSN 1661-7827
1660-4601
Keyword(s) cardiovascular disease
cost-effective analysis
multicomponent
primary prevention
sedentary behaviour
workplace intervention
Science & Technology
Life Sciences & Biomedicine
Environmental Sciences
Public, Environmental & Occupational Health
Environmental Sciences & Ecology
ALL-CAUSE MORTALITY
SEDENTARY TIME
RISK
ASSOCIATION
BIOMARKERS
BEHAVIORS
AUSTRALIA
ADULTS
Summary OBJECTIVES: To assess the cost-effectiveness of workplace-delivered interventions designed to reduce sitting time as primary prevention measures for cardiovascular disease (CVD) in Australia. METHODS: A Markov model was developed to simulate the lifetime cost-effectiveness of a workplace intervention for the primary prevention of CVD amongst office-based workers. An updated systematic review and a meta-analysis of workplace interventions that aim to reduce sitting time was conducted to inform the intervention effect. The primary outcome was workplace standing time. An incremental cost-effectiveness ratio (ICER) was calculated for this intervention measured against current practice. Costs (in Australia dollars) and benefits were discounted at 3% annually. Both deterministic (DSA) and probabilistic (PSA) sensitivity analyses were performed. RESULTS: The updated systematic review identified only one new study. Only the multicomponent intervention that included a sit-and-stand workstation showed statistically significant changes in the standing time compared to the control. The intervention was associated with both higher costs ($6820 versus $6524) and benefits (23.28 versus 23.27, quality-adjusted life year, QALYs), generating an ICER of $43,825/QALY. The DSA showed that target age group for the intervention, relative risk of CVD relative to the control and intervention cost were the key determinants of the ICER. The base case results were within the range of the 95% confidence interval and the intervention had a 85.2% probability of being cost-effective. CONCLUSIONS: A workplace-delivered intervention in the office-based setting including a sit-and-stand desk component is a cost-effective strategy for the primary prevention of CVD. It offers a new option and location when considering interventions to target the growing CVD burden.
Language eng
DOI 10.3390/ijerph16050834
Field of Research MD Multidisciplinary
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2019, The Authors
Persistent URL http://hdl.handle.net/10536/DRO/DU:30120704

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